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anti-MMP13 antibody :: Rabbit MMP13 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821505
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MMP13, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-MMP13 Antibody

 Product Synonym Names    Collagenase 3; Matrix metalloproteinase-13; MMP-13
 Product Gene Name   

anti-MMP13 antibody

[Similar Products]
 Antibody/Peptide Pairs    MMP13 peptide (MBS822998) is used for blocking the activity of MMP13 antibody (MBS821505)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 602111
 3D Structure    ModBase 3D Structure for P45452
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Specificity    Recognizes endogenous levels of MMP13 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP13. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MMP13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MMP13 antibody

   Rabbit polyclonal antibody to MMP13
 Applications Tested/Suitable for anti-MMP13 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-MMP13 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-MMP13 antibody    anti-MMP13 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MMP13 antibody    Immunohistochemical analysis of MMP13 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-MMP13 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-MMP13 antibody    Immunofluorescent analysis of MMP13 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-MMP13 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for MMP13. It may not necessarily be applicable to this product.
 NCBI GI #    4505209
 NCBI GeneID    4322
 NCBI Accession #    NP_002418.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002427.3 [Other Products]
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 UniProt Primary Accession #    P45452 [Other Products]
 UniProt Secondary Accession #    Q6NWN6; A8K846; B2RCZ3 [Other Products]
 UniProt Related Accession #    P45452 [Other Products]
 Molecular Weight    53,820 Da
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 NCBI Official Full Name    collagenase 3 preproprotein
 NCBI Official Synonym Full Names    matrix metallopeptidase 13 (collagenase 3)
 NCBI Official Symbol    MMP13 [Similar Products]
 NCBI Official Synonym Symbols   
CLG3; MANDP1; MMP-13
[Similar Products]
 NCBI Protein Information    collagenase 3; matrix metalloproteinase 13 (collagenase 3)
 UniProt Protein Name    Collagenase 3
 UniProt Synonym Protein Names   
Matrix metalloproteinase-13; MMP-13
 Protein Family    Collagenase
 UniProt Gene Name    MMP13 [Similar Products]
 UniProt Synonym Gene Names    MMP-13 [Similar Products]
 UniProt Entry Name    MMP13_HUMAN
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 NCBI Summary for MMP13    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MMP13    MMP13: Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process. Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO). A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age. Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1). Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.-; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: collagen binding; zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cellular protein metabolic process; proteolysis; bone mineralization; endochondral ossification

Disease: Spondyloepimetaphyseal Dysplasia, Missouri Type
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 Research Articles on MMP13    1. These in vivo findings suggest a role for metalloproteinase-13 in the development and progression of adult human dental tissue disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MMP13 antibodyPathways associated with anti-MMP13 antibody
 Reference Product  PubMed Publications
 MMP3 antibody  >127 publications with MMP13 and MMP3
 RUNX2 antibody  >61 publications with MMP13 and RUNX2
 MMP14 antibody  >52 publications with MMP13 and MMP14
 ADAMTS5 antibody  >38 publications with MMP13 and ADAMTS5
 IL6 antibody  >24 publications with MMP13 and IL6
 IL1B antibody  >17 publications with MMP13 and IL1B
 COL18A1 antibody  >2 publications with MMP13 and COL18A1
 TGFBI antibody  >1 publications with MMP13 and TGFBI
 PLG antibody  >1 publications with MMP13 and PLG
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
Diseases associated with anti-MMP13 antibodyOrgans/Tissues associated with anti-MMP13 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >179 publications with MMP13 and Inflammation
 Disease Models, Animal Antibodies  >154 publications with MMP13 and Disease Models, Animal
 Necrosis Antibodies  >147 publications with MMP13 and Necrosis
 Fibrosis Antibodies  >98 publications with MMP13 and Fibrosis
 Hypertrophy Antibodies  >63 publications with MMP13 and Hypertrophy
 Liver Diseases Antibodies  >61 publications with MMP13 and Liver Diseases
 Neoplasm Metastasis Antibodies  >53 publications with MMP13 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >47 publications with MMP13 and Breast Neoplasms
 Lung Diseases Antibodies  >35 publications with MMP13 and Lung Diseases
 Heart Diseases Antibodies  >28 publications with MMP13 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >361 publications with MMP13 and Bone
 Connective Tissue Antibodies  >173 publications with MMP13 and Connective Tissue
 Mouth Antibodies  >59 publications with MMP13 and Mouth
 Embryonic Tissue Antibodies  >58 publications with MMP13 and Embryonic Tissue
 Lung Antibodies  >53 publications with MMP13 and Lung
 Bone Marrow Antibodies  >52 publications with MMP13 and Bone Marrow
 Brain Antibodies  >20 publications with MMP13 and Brain
 Prostate Antibodies  >17 publications with MMP13 and Prostate
 Intestine Antibodies  >16 publications with MMP13 and Intestine
 Thyroid Antibodies  >11 publications with MMP13 and Thyroid
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