NP_055299.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
49,669 Da
NCBI Official Full Name
adenylyltransferase and sulfurtransferase MOCS3
NCBI Official Synonym Full Names
molybdenum cofactor synthesis 3
NCBI Official Synonym Symbols
NCBI Protein Information
adenylyltransferase and sulfurtransferase MOCS3
UniProt Protein Name
Adenylyltransferase and sulfurtransferase MOCS3
UniProt Synonym Protein Names
Sulfur carrier protein MOCS2A sulfurtransferase
UniProt Synonym Gene Names
UniProt Entry Name
MOCS3_HUMAN
NCBI Summary for MOCS3
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
UniProt Comments for MOCS3
MOCS3: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Protein type: EC 2.8.1.11; Ligase; EC 2.7.7.80; Transferase
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: cytosol
Molecular Function: nucleotidyltransferase activity; protein binding; sulfurtransferase activity; thiosulfate sulfurtransferase activity; URM1 activating enzyme activity
Biological Process: enzyme active site formation via L-cysteine persulfide; Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; protein urmylation; tRNA wobble uridine modification
Research Articles on MOCS3
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Pathways associated with anti-MOCS3 antibody
Diseases associated with anti-MOCS3 antibody
Organs/Tissues associated with anti-MOCS3 antibody
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