NP_000905.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
SDS-PAGE MW: 45kd
NCBI Official Full Name
mu-type opioid receptor isoform MOR-1
NCBI Official Synonym Full Names
opioid receptor, mu 1
NCBI Official Synonym Symbols
MOP; MOR; LMOR; MOR1; OPRM; M-OR-1 [Similar Products]
NCBI Protein Information
mu-type opioid receptor
UniProt Protein Name
Mu-type opioid receptor
UniProt Synonym Protein Names
Mu opiate receptor; Mu opioid receptor; MOP; hMOP
UniProt Synonym Gene Names
UniProt Entry Name
OPRM_HUMAN
NCBI Summary for MOR-1
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
UniProt Comments for MOR-1
MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 6q24-q25
Cellular Component: dendrite cytoplasm; Golgi apparatus; neuron projection; focal adhesion; integral to plasma membrane; endoplasmic reticulum; plasma membrane; perikaryon; sarcolemma; lipid raft
Molecular Function: G-protein coupled receptor activity; voltage-gated calcium channel activity; neuropeptide binding; protein domain specific binding; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; filamin binding; beta-endorphin receptor activity
Biological Process: response to food; positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; wound healing; cellular response to stress; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; response to lipopolysaccharide; locomotory behavior; behavioral response to ethanol; sensory perception of pain; response to cocaine; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; reduction of cytosolic calcium ion concentration; positive regulation of appetite; sensory perception; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; acute inflammatory response to antigenic stimulus; dopamine receptor, adenylate cyclase activating pathway
Disease: Epilepsy, Idiopathic Generalized
Research Articles on MOR-1
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Products associated with anti-MOR-1 antibody
Pathways associated with anti-MOR-1 antibody
Diseases associated with anti-MOR-1 antibody
Organs/Tissues associated with anti-MOR-1 antibody
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