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anti-KAT6A antibody :: Rabbit anti-Mouse MOZ/MYST3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205613
Western Blot (WB)
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MOZ/MYST3 (KAT6A), Polyclonal Antibody

 Also Known As   

MOZ/MYST3 Antibody (C-term)

 Product Synonym Names    Histone acetyltransferase KAT6A; MOZ; YBF2/SAS3; SAS2 and TIP60 protein 3; MYST-3; Monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220; KAT6A; MOZ; MYST3; RUNXBP2; ZNF220
 Product Gene Name   

anti-KAT6A antibody

[Similar Products]
 Antibody/Peptide Pairs    MOZ/MYST3 peptide (MBS9218927) is used for blocking the activity of MOZ/MYST3 antibody (MBS9205613)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1319-1351
 OMIM    601408
 3D Structure    ModBase 3D Structure for Q92794
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    This MOZ/MYST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1319-1351 amino acids from the C-terminal region of human MOZ/MYST3.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-KAT6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KAT6A antibody

   Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Histone acetyltransferase which may act as a transcriptional coactivator for RUNX1 and RUNX2.
 Applications Tested/Suitable for anti-KAT6A antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-KAT6A antibody    WB~~1:1000
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 Western Blot (WB) of anti-KAT6A antibody    MOZ/MYST3 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the MOZ/MYST3 antibody detected the MOZ/MYST3 protein (arrow).
anti-KAT6A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KAT6A. It may not necessarily be applicable to this product.
 NCBI GI #    150378463
 NCBI GeneID    7994
 NCBI Accession #    NP_001092882.1 [Other Products]
 NCBI Related Accession #    NP_001092883.1; NP_006757.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001099412.1 [Other Products]
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 UniProt Primary Accession #    Q92794 [Other Products]
 UniProt Secondary Accession #    Q76L81 [Other Products]
 UniProt Related Accession #    Q92794 [Other Products]
 Molecular Weight    225028
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 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 6A
 NCBI Official Symbol    KAT6A [Similar Products]
 NCBI Official Synonym Symbols   
MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT6A
 UniProt Protein Name    Histone acetyltransferase KAT6A
 UniProt Synonym Protein Names   
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST-3; Monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220
 Protein Family    Histone acetyltransferase
 UniProt Gene Name    KAT6A [Similar Products]
 UniProt Synonym Gene Names    MOZ; MYST3; RUNXBP2; ZNF220; MYST-3 [Similar Products]
 UniProt Entry Name    KAT6A_HUMAN
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 NCBI Summary for KAT6A    This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
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 UniProt Comments for KAT6A    MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family.

Protein type: Nucleolus; EC 2.3.1.48; Oncoprotein; Acetyltransferase

Chromosomal Location of Human Ortholog: 8p11

Cellular Component: nucleoplasm; Golgi apparatus; PML body; nucleolus; nucleosome; nucleus

Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; zinc ion binding; acetyltransferase activity; transcription coactivator activity; chromatin binding; transcription factor binding

Biological Process: heart morphogenesis; nucleosome assembly; establishment and/or maintenance of chromatin architecture; protein amino acid acetylation; transcription, DNA-dependent; embryonic hemopoiesis; somatic stem cell maintenance; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; histone acetylation; negative regulation of transcription, DNA-dependent; DNA packaging

Disease: Mental Retardation, Autosomal Dominant 32
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Product References and Citations for anti-KAT6A antibody

   Paggetti, J., et al. Oncogene 29(36):5019-5031(2010)
Rokudai, S., et al. J. Biol. Chem. 284(1):237-244(2009)
Murati, A., et al. Leukemia 23(1):85-94(2009)
Ullah, M., et al. Mol. Cell. Biol. 28(22):6828-6843(2008)
Katsumoto, T., et al. Cancer Sci. 99(8):1523-1527(2008)
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 Research Articles on KAT6A    1. These data suggest that KAT6A may be a novel oncogene in breast cancers bearing the 8p11-p12 amplicon.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KAT6A antibodyDiseases associated with anti-KAT6A antibody
 Reference Product  PubMed Publications
 CREBBP antibody  >18 publications with KAT6A and CREBBP
 KAT6B antibody  >16 publications with KAT6A and KAT6B
 RUNX1 antibody  >8 publications with KAT6A and RUNX1
 BRPF1 antibody  >8 publications with KAT6A and BRPF1
 ING5 antibody  >5 publications with KAT6A and ING5
 TP53 antibody  >2 publications with KAT6A and TP53
 SPI1 antibody  >1 publications with KAT6A and SPI1
 BRPF3 antibody  >1 publications with KAT6A and BRPF3
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >30 publications with KAT6A and Chromosome Aberrations
 Cell Transformation, Neoplastic Antibodies  >4 publications with KAT6A and Cell Transformation, Neoplastic
 Abnormalities, Multiple Antibodies  >4 publications with KAT6A and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >4 publications with KAT6A and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >3 publications with KAT6A and Craniofacial Abnormalities
 Disease Models, Animal Antibodies  >2 publications with KAT6A and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >1 publications with KAT6A and Neoplasm Metastasis
 Uterine Neoplasms Antibodies  >1 publications with KAT6A and Uterine Neoplasms
 Hyperplasia Antibodies  >1 publications with KAT6A and Hyperplasia
 Memory Disorders Antibodies  >1 publications with KAT6A and Memory Disorders
Organs/Tissues associated with anti-KAT6A antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with KAT6A and Blood
 Bone Antibodies  >7 publications with KAT6A and Bone
 Bone Marrow Antibodies  >5 publications with KAT6A and Bone Marrow
 Embryonic Tissue Antibodies  >3 publications with KAT6A and Embryonic Tissue
 Brain Antibodies  >3 publications with KAT6A and Brain
 Placenta Antibodies  >2 publications with KAT6A and Placenta
 Heart Antibodies  >2 publications with KAT6A and Heart
 Pharynx Antibodies  >1 publications with KAT6A and Pharynx
 Testis Antibodies  >1 publications with KAT6A and Testis
 Prostate Antibodies  >1 publications with KAT6A and Prostate
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