NP_059990.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 97 kDa Predicted: 98 kDa
NCBI Official Full Name
M-phase phosphoprotein 8
NCBI Official Synonym Full Names
M-phase phosphoprotein 8
NCBI Protein Information
M-phase phosphoprotein 8
UniProt Protein Name
M-phase phosphoprotein 8
UniProt Synonym Protein Names
Two hybrid-associated protein 3 with RanBPM
UniProt Synonym Gene Names
UniProt Comments for MPHOSPH8
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Research Articles on MPHOSPH8
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Organs/Tissues associated with anti-MPHOSPH8 antibody
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