NP_000241.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,248 Da
NCBI Official Full Name
myeloperoxidase
NCBI Official Synonym Full Names
myeloperoxidase
NCBI Protein Information
myeloperoxidase
UniProt Protein Name
Myeloperoxidase
UniProt Synonym Gene Names
UniProt Entry Name
PERM_HUMAN
NCBI Summary for MPO
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
UniProt Comments for MPO
MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.11.2.2; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule
Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding
Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; response to lipopolysaccharide; response to yeast; defense response; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging
Disease: Myeloperoxidase Deficiency; Alzheimer Disease
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Products associated with anti-MPO antibody
Pathways associated with anti-MPO antibody
Diseases associated with anti-MPO antibody
Organs/Tissues associated with anti-MPO antibody
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