CAG30409.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
MPST
NCBI Official Synonym Full Names
mercaptopyruvate sulfurtransferase
NCBI Official Synonym Symbols
NCBI Protein Information
3-mercaptopyruvate sulfurtransferase; human liver rhodanese
UniProt Protein Name
3-mercaptopyruvate sulfurtransferase
UniProt Synonym Gene Names
UniProt Entry Name
THTM_HUMAN
NCBI Summary for MPST
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MPST
MPST: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.
Protein type: Transferase; EC 2.8.1.2; Amino Acid Metabolism - cysteine and methionine; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: neuron projection; mitochondrial inner membrane; synapse; cell junction
Molecular Function: 3-mercaptopyruvate sulfurtransferase activity; thiosulfate sulfurtransferase activity
Biological Process: cyanate catabolic process; response to toxin
Research Articles on MPST
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Products associated with anti-MPST antibody
Pathways associated with anti-MPST antibody
Diseases associated with anti-MPST antibody
Organs/Tissues associated with anti-MPST antibody
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