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anti-ABCC5 antibody :: Goat MRP5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420328
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MRP5 (ABCC5), Polyclonal Antibody

 Also Known As   

Goat anti-MRP5 Antibody

 Product Synonym Names    MRP5; DKFZp686C1782; ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ABC33; EST277145; MOAT-C; MOATC; SMRP; pABC11; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; MRP5 antibody; DKFZp686C1782 antibody; ABCC5 antibody; ATP-binding cassette; sub-family C (CFTR/MRP); member 5 antibody; ABC33 antibody; EST277145 antibody; MOAT-C antibody; MOATC antibody; SMRP antibody; pABC11 antibody; ATP-binding cassette; sub-family C; member 5 antibody; canalicular multispecific organic anion transporter C antibody
 Product Gene Name   

anti-ABCC5 antibody

[Similar Products]
 Product Synonym Gene Name    MRP5 [Similar Products]
 Antibody/Peptide Pairs    MRP5 peptide (MBS426635) is used for blocking the activity of MRP5 antibody (MBS420328)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KDIDIGKEYI IP
 OMIM    605251
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KDIDIGKEYIIP-C, from the N Terminus of the protein sequence according to NP_005679.2; NP_001018881.1.
 Epitope    N Terminus
 Note    This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ABCC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ABCC5 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ABCC5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Kidney shows membranous staining in DCT. Recommended concentration, 4-6ug/ml.
Western Blot: Approx.150kDa band observed in Human Brain (Frnotal Cortex) and Mouse Brain lysates (calculated MW of 161kDa according to NP_005679.2). Recommended concentration: 0.5-1.5ug/ml.
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 Western Blot (WB) of anti-ABCC5 antibody    (0.5ug/ml) staining of Human Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABCC5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ABCC5 antibody    (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Similar results with antigen retrieval at pH9.
anti-ABCC5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ABCC5. It may not necessarily be applicable to this product.
 NCBI GI #    66529005
 NCBI GeneID    10057
 NCBI Accession #    NP_005679.2 [Other Products]
 NCBI Related Accession #    NP_001018881.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005688.3 [Other Products]
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 UniProt Secondary Accession #    O14517; Q29ZA9; Q29ZB1; Q86UX3; Q86W30; Q9UN85; Q9UNP5; Q9UQC3; B9EIQ2 [Other Products]
 UniProt Related Accession #    O15440 [Other Products]
 Molecular Weight    155,732 Da
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 NCBI Official Full Name    multidrug resistance-associated protein 5 isoform 1
 NCBI Official Synonym Full Names    ATP binding cassette subfamily C member 5
 NCBI Official Symbol    ABCC5 [Similar Products]
 NCBI Official Synonym Symbols   
MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145
[Similar Products]
 NCBI Protein Information    multidrug resistance-associated protein 5
 UniProt Protein Name    Multidrug resistance-associated protein 5
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11
 Protein Family    Multidrug resistance-associated protein
 UniProt Gene Name    ABCC5 [Similar Products]
 UniProt Synonym Gene Names    MRP5; MOAT-C [Similar Products]
 UniProt Entry Name    MRP5_HUMAN
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 NCBI Summary for ABCC5    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ABCC5    ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATP binding; organic anion transmembrane transporter activity

Biological Process: hyaluronan biosynthetic process; organic anion transport; transmembrane transport; transport
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 Research Articles on ABCC5    1. ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABCC5 antibodyDiseases associated with anti-ABCC5 antibody
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Biosynthesis And Export Pathway antibodies  Hyaluronan Biosynthesis And Export Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >31 publications with ABCC5 and Carcinoma
 Breast Neoplasms Antibodies  >16 publications with ABCC5 and Breast Neoplasms
 Adenocarcinoma Antibodies  >13 publications with ABCC5 and Adenocarcinoma
 Nervous System Diseases Antibodies  >10 publications with ABCC5 and Nervous System Diseases
 Colorectal Neoplasms Antibodies  >10 publications with ABCC5 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >9 publications with ABCC5 and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >9 publications with ABCC5 and Pancreatic Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with ABCC5 and Neoplasms, Experimental
 Inflammation Antibodies  >8 publications with ABCC5 and Inflammation
 Disease Models, Animal Antibodies  >8 publications with ABCC5 and Disease Models, Animal
Organs/Tissues associated with anti-ABCC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with ABCC5 and Brain
 Lung Antibodies  >15 publications with ABCC5 and Lung
 Intestine Antibodies  >10 publications with ABCC5 and Intestine
 Eye Antibodies  >8 publications with ABCC5 and Eye
 Bone Antibodies  >3 publications with ABCC5 and Bone
 Prostate Antibodies  >3 publications with ABCC5 and Prostate
 Connective Tissue Antibodies  >2 publications with ABCC5 and Connective Tissue
 Skin Antibodies  >2 publications with ABCC5 and Skin
 Stomach Antibodies  >2 publications with ABCC5 and Stomach
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