NP_002377.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 35 kDa Predicted: 35 kDa
NCBI Official Full Name
melanocyte-stimulating hormone receptor
NCBI Official Synonym Full Names
melanocortin 1 receptor
NCBI Protein Information
melanocyte-stimulating hormone receptor
UniProt Protein Name
Melanocyte-stimulating hormone receptor
UniProt Synonym Protein Names
Melanocortin receptor 1; MC1-R
UniProt Synonym Gene Names
NCBI Summary for MSHR
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
UniProt Comments for MSHR
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Research Articles on MSHR
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Products associated with anti-MSHR antibody
Pathways associated with anti-MSHR antibody
Diseases associated with anti-MSHR antibody
Organs/Tissues associated with anti-MSHR antibody
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