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anti-MSR1 antibody :: Rabbit anti-Human, Mouse MSR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048688
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MSR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MSR1 Antibody

 Product Synonym Names    Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD204; MSR1; SCARA1
 Product Gene Name   

anti-MSR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    D90187 mRNA
 3D Structure    ModBase 3D Structure for P21757
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Macrophage scavenger receptor types I and II protein (271-446AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20441 / sc-20660
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MSR1 antibody

   Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
 Applications Tested/Suitable for anti-MSR1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MSR1 antibody    WB: 1: 2000-1: 10000
IHC: 1: 20-1: 200
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 Western Blot (WB) of anti-MSR1 antibody    Western Blot
Positive WB detected in:THP-1 whole cell lysate,Hela whole cell lysate,Mouse spleen tissue,Mouse lung tissue,Mouse brain tissue,Mouse stomach tissue
All lanes: MSR1 antibody at 1.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50,40,43 kDa
Observed band size: 50 kDa

anti-MSR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MSR1 antibody    Immunohistochemistry of paraffin-embedded human heart tissue using MBS7048688 at dilution of 1:100
anti-MSR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MSR1. It may not necessarily be applicable to this product.
 NCBI GI #    4505259
 NCBI GeneID    4481
 NCBI Accession #    NP_002436.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002445.3 [Other Products]
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 UniProt Primary Accession #    P21757 [Other Products]
 UniProt Secondary Accession #    O60505; P21759; Q45F10; D3DSP3 [Other Products]
 UniProt Related Accession #    P21757 [Other Products]
 Molecular Weight    42,942 Da
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 NCBI Official Full Name    macrophage scavenger receptor types I and II isoform type 2
 NCBI Official Synonym Full Names    macrophage scavenger receptor 1
 NCBI Official Symbol    MSR1 [Similar Products]
 NCBI Official Synonym Symbols   
SRA; SR-A; CD204; phSR1; phSR2; SCARA1
[Similar Products]
 NCBI Protein Information    macrophage scavenger receptor types I and II
 UniProt Protein Name    Macrophage scavenger receptor types I and II
 UniProt Synonym Protein Names   
Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD_antigen: CD204
 Protein Family    Macrophage scavenger receptor
 UniProt Gene Name    MSR1 [Similar Products]
 UniProt Synonym Gene Names    SCARA1 [Similar Products]
 UniProt Entry Name    MSRE_HUMAN
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 NCBI Summary for MSR1    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MSR1    MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: low-density lipoprotein binding; protein binding

Biological Process: cholesterol transport; receptor-mediated endocytosis

Disease: Barrett Esophagus; Prostate Cancer
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 Research Articles on MSR1    1. We also demonstrate that across the human genome, the presence of MSR1 repeats in the promoters or first introns of genes is associated with greater population variability in gene expression indicating that copy number variation of MSR1s is a generic controller of gene expression and promises to provide new insights into our understanding of gene expression regulation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MSR1 antibodyPathways associated with anti-MSR1 antibody
 Reference Product  PubMed Publications
 CD36 antibody  >48 publications with MSR1 and CD36
 RNASEL antibody  >26 publications with MSR1 and RNASEL
 ELAC2 antibody  >17 publications with MSR1 and ELAC2
 APOE antibody  >16 publications with MSR1 and APOE
 APOB antibody  >2 publications with MSR1 and APOB
 TRAF6 antibody  >1 publications with MSR1 and TRAF6
 APOA1 antibody  >1 publications with MSR1 and APOA1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
Diseases associated with anti-MSR1 antibodyOrgans/Tissues associated with anti-MSR1 antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >63 publications with MSR1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >55 publications with MSR1 and Cardiovascular Diseases
 Inflammation Antibodies  >49 publications with MSR1 and Inflammation
 Prostatic Neoplasms Antibodies  >46 publications with MSR1 and Prostatic Neoplasms
 Lung Diseases Antibodies  >29 publications with MSR1 and Lung Diseases
 Necrosis Antibodies  >28 publications with MSR1 and Necrosis
 Disease Models, Animal Antibodies  >25 publications with MSR1 and Disease Models, Animal
 Fibrosis Antibodies  >12 publications with MSR1 and Fibrosis
 Neoplasms, Experimental Antibodies  >12 publications with MSR1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >12 publications with MSR1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >94 publications with MSR1 and Blood
 Vascular Antibodies  >34 publications with MSR1 and Vascular
 Lung Antibodies  >34 publications with MSR1 and Lung
 Liver Antibodies  >28 publications with MSR1 and Liver
 Kidney Antibodies  >11 publications with MSR1 and Kidney
 Heart Antibodies  >11 publications with MSR1 and Heart
 Brain Antibodies  >11 publications with MSR1 and Brain
 Connective Tissue Antibodies  >6 publications with MSR1 and Connective Tissue
 Spleen Antibodies  >5 publications with MSR1 and Spleen
 Placenta Antibodies  >2 publications with MSR1 and Placenta
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