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anti-MSTN antibody :: Rabbit anti-Human MSTN / GDF8 / Myostatin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240197
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MSTN / GDF8 / Myostatin, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MSTN / GDF8 / Myostatin

 Product Synonym Names    Anti-MSTN / GDF8 / Myostatin Antibody IHC-plus; MSTN; GDF8; MSLHP; Myostatin; GDF-8; Human MSTN; GDF8; Myostatin
 Product Gene Name   

anti-MSTN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614160
 3D Structure    ModBase 3D Structure for O14793
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Amino acids 24 - 39 [NENSEQKENVEKEGLC] of the human myostatin.
 Immunogen Type    Synthetic peptide
 Immunogen    MSTN / GDF8 / Myostatin antibody was raised against amino acids 24 - 39 [NENSEQKENVEKEGLC] of the human myostatin.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-MSTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MSTN antibody

   Myostatin (MSTN) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
 Product Categories/Family for anti-MSTN antibody    Family: TGF beta
 Applications Tested/Suitable for anti-MSTN antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-MSTN antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
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 Immunohistochemistry (IHC) of anti-MSTN antibody    Anti-MSTN / Myostatin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MSTN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MSTN. It may not necessarily be applicable to this product.
 NCBI GI #    4885259
 NCBI GeneID    2660
 NCBI Accession #    NP_005250.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005259.2 [Other Products]
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 UniProt Primary Accession #    O14793 [Other Products]
 UniProt Secondary Accession #    Q6B0H2; A1C2J7; A1C2K0 [Other Products]
 UniProt Related Accession #    O14793 [Other Products]
 Molecular Weight    42,750 Da
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 NCBI Official Full Name    growth/differentiation factor 8
 NCBI Official Synonym Full Names    myostatin
 NCBI Official Symbol    MSTN [Similar Products]
 NCBI Official Synonym Symbols   
GDF8; MSLHP
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 8; GDF-8; growth differentiation factor 8
 UniProt Protein Name    Growth/differentiation factor 8
 UniProt Synonym Protein Names   
Myostatin
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    MSTN [Similar Products]
 UniProt Synonym Gene Names    GDF8; GDF-8 [Similar Products]
 UniProt Entry Name    GDF8_HUMAN
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 NCBI Summary for MSTN    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MSTN    MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: response to gravity; response to muscle activity; muscle development; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; regulation of apoptosis; ovulation cycle process; skeletal muscle atrophy; negative regulation of muscle hypertrophy; response to ethanol; response to heat; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; negative regulation of skeletal muscle growth; response to electrical stimulus; cell development

Disease: Muscle Hypertrophy
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 Research Articles on MSTN    1. The present study demonstrated that the variant alleles of MSTN A55T and K153R polymorphisms could significantly enhance muscle hypertrophy in response to strength training among Han Chinese men.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MSTN antibody
 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
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