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anti-ATP6 antibody :: Goat MT-ATP6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS423307
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MT-ATP6, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-MT-ATP6 Antibody

 Product Synonym Names    ATP6; MT-ATP6; ATPase6; MTATP6; ATP6 antibody; MT-ATP6 antibody; ATPase6 antibody; MTATP6 antibody
 Product Gene Name   

anti-ATP6 antibody

[Similar Products]
 Product Synonym Gene Name    MT-ATP6 [Similar Products]
 Antibody/Peptide Pairs    MT-ATP6 peptide (MBS428320) is used for blocking the activity of MT-ATP6 antibody (MBS423307)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PTSKYLINNR LITTQ
 OMIM    256000
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PTSKYLINNRLITTQ, from the internal region of the protein sequence according to YP_003024031.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ATP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ATP6 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ATP6 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 26kDa band observed in Human Heart, Colon and Ileum lysates (calculated MW of 24.8kDa according to YP_003024031.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-ATP6 antibody    (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ATP6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ATP6. It may not necessarily be applicable to this product.
 NCBI GI #    251831112
 NCBI GeneID    4508
 NCBI Accession #    YP_003024031.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_012920.1 [Other Products]
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 UniProt Secondary Accession #    Q34772; Q5S8W5; Q5S9E7; Q5S9I6; Q5SA31; Q6RPB7; Q6VHC0; Q6VHE0; Q6WQF4; Q7YCC1; Q7YCF8 [Other Products]
 Molecular Weight    24,817 Da
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 NCBI Official Full Name    ATP synthase F0 subunit 6 (mitochondrion)
 NCBI Official Synonym Full Names    mitochondrially encoded ATP synthase 6
 NCBI Official Symbol    MT-ATP6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ATP synthase F0 subunit 6
 UniProt Protein Name    ATP synthase subunit a
 UniProt Synonym Protein Names   
F-ATPase protein 6
 UniProt Gene Name    MT-ATP6 [Similar Products]
 UniProt Synonym Gene Names    ATP6; ATPASE6; MTATP6 [Similar Products]
 UniProt Entry Name    ATP6_HUMAN
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 UniProt Comments for ATP6    ATP6: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane. Defects in MT-ATP6 are the cause of neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP). Defects in MT-ATP6 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ATP6 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ATP6 are a cause of mitochondrial infantile bilateral striatal necrosis (MIBSN). Bilateral striatal necrosis is a neurological disorder resembling Leigh syndrome. Belongs to the ATPase A chain family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: -

Disease: Leber Optic Atrophy; Neuropathy, Ataxia, And Retinitis Pigmentosa
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 Research Articles on ATP6    1. Two synonymous substitutions (mt.8614T>C and mt.8994G>A) in the mt-ATP6 gene may be associated with childhood obesity; study provides first data about mitochondrial genome variations in a Turkish obese population and also the first in obese children
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ATP6 antibody
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 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
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 Metabolism Pathway antibodies  Metabolism Pathway Diagram
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