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anti-MTHFD2 antibody :: Rabbit anti-Human MTHFD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044183
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTHFD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

MTHFD2 Antibody

 Product Synonym Names    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylenetetrahydrofolate dehydrogenase; MTHFD2; NMDMC
 Product Gene Name   

anti-MTHFD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604887
 3D Structure    ModBase 3D Structure for P13995
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial protein (40-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74986 / sc-74985 / sc-74984
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MTHFD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MTHFD2 antibody

   extracellular space, mitochondrial matrix, mitochondrion, magnesium ion binding, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, phosphate ion binding, folic acid metabolic process, one-carbon metabolic process
 Applications Tested/Suitable for anti-MTHFD2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-MTHFD2 antibody    Western blot
All lanes: MTHFD2 antibody at 4.99 ug/ml
Lane 1: A431 whole cell lysate
Lane 2: HepG-2 whole cell lysate
Lane 3: Hela whole cell lysate
Lane 4: Raji whole cell lysate
Lane 5: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 38,27 kDa
Observed band size: 38,30,95 kDa

anti-MTHFD2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MTHFD2 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7044183 at dilution of 1:100
anti-MTHFD2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MTHFD2 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7044183 at dilution of 1:100
anti-MTHFD2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MTHFD2. It may not necessarily be applicable to this product.
 NCBI GI #    94721354
 NCBI GeneID    10797
 NCBI Accession #    NP_006627.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006636.3 [Other Products]
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 UniProt Primary Accession #    P13995 [Other Products]
 UniProt Secondary Accession #    Q53G90; Q53GV5; Q53S36; Q7Z650 [Other Products]
 UniProt Related Accession #    P13995 [Other Products]
 Molecular Weight    26,849 Da
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 NCBI Official Full Name    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
 NCBI Official Synonym Full Names    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
 NCBI Official Symbol    MTHFD2 [Similar Products]
 NCBI Official Synonym Symbols   
NMDMC
[Similar Products]
 NCBI Protein Information    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
 UniProt Protein Name    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
 Protein Family    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
 UniProt Gene Name    MTHFD2 [Similar Products]
 UniProt Synonym Gene Names    NMDMC [Similar Products]
 UniProt Entry Name    MTDC_HUMAN
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 NCBI Summary for MTHFD2    This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
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 UniProt Comments for MTHFD2    MTHFD2: a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Hydrolase; EC 1.5.1.15; Mitochondrial; EC 3.5.4.9; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytosol; extracellular space; mitochondrial matrix; mitochondrion

Molecular Function: formate-tetrahydrofolate ligase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate binding

Biological Process: folic acid metabolic process; one-carbon compound metabolic process; tetrahydrofolate metabolic process
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 Research Articles on MTHFD2    1. These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MTHFD2 antibodyDiseases associated with anti-MTHFD2 antibody
 Products by Pathway  Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Folate And Pterines Pathway antibodies  Metabolism Of Folate And Pterines Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with MTHFD2 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with MTHFD2 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3 publications with MTHFD2 and Adenocarcinoma
 Nervous System Diseases Antibodies  >3 publications with MTHFD2 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with MTHFD2 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with MTHFD2 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with MTHFD2 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with MTHFD2 and Liver Neoplasms
 Neural Tube Defects Antibodies  >2 publications with MTHFD2 and Neural Tube Defects
 Lung Neoplasms Antibodies  >1 publications with MTHFD2 and Lung Neoplasms
Organs/Tissues associated with anti-MTHFD2 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with MTHFD2 and Liver
 Lung Antibodies  >2 publications with MTHFD2 and Lung
 Embryonic Tissue Antibodies  >2 publications with MTHFD2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with MTHFD2 and Muscle
 Heart Antibodies  >2 publications with MTHFD2 and Heart
 Bone Antibodies  >1 publications with MTHFD2 and Bone
 Ovary Antibodies  >1 publications with MTHFD2 and Ovary
 Lymph Antibodies  >1 publications with MTHFD2 and Lymph
 Lymph Node Antibodies  >1 publications with MTHFD2 and Lymph Node
 Bladder Antibodies  >1 publications with MTHFD2 and Bladder
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