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anti-MTHFR antibody :: MTHFR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820888
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTHFR, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-MTHFR Antibody

 Product Synonym Names    Methylenetetrahydrofolate reductase
 Product Gene Name   

anti-MTHFR antibody

[Similar Products]
 Antibody/Peptide Pairs    MTHFR peptide (MBS824338) is used for blocking the activity of MTHFR antibody (MBS820888)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607093
 3D Structure    ModBase 3D Structure for P42898
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Monkey
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 Specificity    Recognizes endogenous levels of MTHFR protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MTHFR. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MTHFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MTHFR antibody

   Rabbit polyclonal antibody to MTHFR
 Applications Tested/Suitable for anti-MTHFR antibody   

Western Blot (WB)

 Application Notes for anti-MTHFR antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-MTHFR antibody    Western blot analysis of MTHFR expression in HEK293 (A), Jurkat (B), A549 (C) whole cell lysates.
anti-MTHFR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MTHFR. It may not necessarily be applicable to this product.
 NCBI GI #    87240000
 NCBI GeneID    4524
 NCBI Accession #    NP_005948.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005957.4 [Other Products]
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 UniProt Primary Accession #    P42898 [Other Products]
 UniProt Secondary Accession #    Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2; B2R7A6 [Other Products]
 UniProt Related Accession #    P42898 [Other Products]
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 NCBI Official Full Name    methylenetetrahydrofolate reductase
 NCBI Official Synonym Full Names    methylenetetrahydrofolate reductase (NAD(P)H)
 NCBI Official Symbol    MTHFR [Similar Products]
 NCBI Protein Information    methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH)
 UniProt Protein Name    Methylenetetrahydrofolate reductase
 Protein Family    Methylenetetrahydrofolate reductase
 UniProt Gene Name    MTHFR [Similar Products]
 UniProt Entry Name    MTHR_HUMAN
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 NCBI Summary for MTHFR    The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
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 UniProt Comments for MTHFR    MTHFR: Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD). MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia, developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD). The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Belongs to the methylenetetrahydrofolate reductase family.

Protein type: EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase; Cofactor and Vitamin Metabolism - one carbon pool by folate

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: neuron projection; cytosol

Molecular Function: FAD binding; NADP binding; methylenetetrahydrofolate reductase (NADPH) activity

Biological Process: amino acid metabolic process; response to drug; vitamin metabolic process; methionine biosynthetic process; blood circulation; response to folic acid; response to vitamin B2; response to hypoxia; S-adenosylmethionine metabolic process; one-carbon compound metabolic process; folic acid metabolic process; homocysteine metabolic process; water-soluble vitamin metabolic process

Disease: Schizophrenia; Thrombophilia Due To Thrombin Defect; Neural Tube Defects, Folate-sensitive; Homocystinuria Due To Deficiency Of N(5,10)-methylenetetrahydrofolate Reductase Activity
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 Research Articles on MTHFR    1. Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MTHFR antibodyPathways associated with anti-MTHFR antibody
 Reference Product  PubMed Publications
 MTR antibody  >270 publications with MTHFR and MTR
 MTRR antibody  >261 publications with MTHFR and MTRR
 TYMS antibody  >125 publications with MTHFR and TYMS
 MTHFD1 antibody  >74 publications with MTHFR and MTHFD1
 SHMT1 antibody  >54 publications with MTHFR and SHMT1
 MTHFD2 antibody  >4 publications with MTHFR and MTHFD2
 AMT antibody  >2 publications with MTHFR and AMT
 SHMT2 antibody  >1 publications with MTHFR and SHMT2
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Diseases associated with anti-MTHFR antibodyOrgans/Tissues associated with anti-MTHFR antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1860 publications with MTHFR and Cardiovascular Diseases
 Vascular Diseases Antibodies  >1650 publications with MTHFR and Vascular Diseases
 Nervous System Diseases Antibodies  >1115 publications with MTHFR and Nervous System Diseases
 Hematologic Diseases Antibodies  >648 publications with MTHFR and Hematologic Diseases
 Venous Thrombosis Antibodies  >506 publications with MTHFR and Venous Thrombosis
 Stroke Antibodies  >423 publications with MTHFR and Stroke
 Coronary Disease Antibodies  >369 publications with MTHFR and Coronary Disease
 Neural Tube Defects Antibodies  >324 publications with MTHFR and Neural Tube Defects
 Colorectal Neoplasms Antibodies  >278 publications with MTHFR and Colorectal Neoplasms
 Skin Diseases Antibodies  >189 publications with MTHFR and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2436 publications with MTHFR and Blood
 Brain Antibodies  >333 publications with MTHFR and Brain
 Heart Antibodies  >321 publications with MTHFR and Heart
 Liver Antibodies  >186 publications with MTHFR and Liver
 Kidney Antibodies  >183 publications with MTHFR and Kidney
 Bone Antibodies  >117 publications with MTHFR and Bone
 Lung Antibodies  >94 publications with MTHFR and Lung
 Stomach Antibodies  >85 publications with MTHFR and Stomach
 Muscle Antibodies  >70 publications with MTHFR and Muscle
 Skin Antibodies  >57 publications with MTHFR and Skin
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