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anti-MTO1 antibody :: Rabbit anti-Human, Rat MTO1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043783
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTO1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MTO1 Antibody

 Product Synonym Names    Protein MTO1 homolog, mitochondrial; MTO1; CGI-02
 Product Gene Name   

anti-MTO1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614667
 3D Structure    ModBase 3D Structure for Q9Y2Z2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Protein MTO1 homolog, mitochondrial protein (420-680AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161114 / sc-161115
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MTO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MTO1 antibody

   Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
 Applications Tested/Suitable for anti-MTO1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-MTO1 antibody    Western blot
All lanes: MTO1 antibody at 2.25 ug/ml
Lane 1: Rat heart tissue
Lane 2: Jurkat whole cell lysate
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 80,67,35,78,73,82 kDa
Observed band size: 80,65,36 kDa

anti-MTO1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MTO1 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7043783 at dilution of 1:100
anti-MTO1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MTO1 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7043783 at dilution of 1:100
anti-MTO1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MTO1. It may not necessarily be applicable to this product.
 NCBI GI #    183227703
 NCBI GeneID    25821
 NCBI Accession #    NP_001116698.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001123226.1 [Other Products]
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 UniProt Primary Accession #    Q9Y2Z2 [Other Products]
 UniProt Secondary Accession #    Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; B3KQB5 [Other Products]
 UniProt Related Accession #    Q9Y2Z2 [Other Products]
 Molecular Weight    81,538 Da
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 NCBI Official Full Name    protein MTO1 homolog, mitochondrial isoform c
 NCBI Official Synonym Full Names    mitochondrial tRNA translation optimization 1
 NCBI Official Symbol    MTO1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein MTO1 homolog, mitochondrial
 UniProt Protein Name    Protein MTO1 homolog, mitochondrial
 Protein Family    Mitochondrial translation optimization protein
 UniProt Gene Name    MTO1 [Similar Products]
 UniProt Entry Name    MTO1_HUMAN
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 NCBI Summary for MTO1    This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MTO1    MTO1: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Defects in MTO1 are the cause of combined oxidative phosphorylation deficiency type 10 (COXPD10). An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases. Belongs to the MnmG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 6q13

Disease: Combined Oxidative Phosphorylation Deficiency 10
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 Research Articles on MTO1    1. Optic neuropathy, cardiomyopathy, and cognitive disability was found in patients with a homozygous mutation in the nuclear MTO1 and a mitochondrial MT-TF variant.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MTO1 antibodyDiseases associated with anti-MTO1 antibody
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Modification In The Mitochondrion Pathway antibodies  TRNA Modification In The Mitochondrion Pathway Diagram
 TRNA Processing Pathway antibodies  TRNA Processing Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with MTO1 and Cardiovascular Diseases
 Atrophy Antibodies  >2 publications with MTO1 and Atrophy
 Neurobehavioral Manifestations Antibodies  >1 publications with MTO1 and Neurobehavioral Manifestations
Organs/Tissues associated with anti-MTO1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with MTO1 and Brain
 Liver Antibodies  >2 publications with MTO1 and Liver
 Heart Antibodies  >2 publications with MTO1 and Heart
 Nerve Antibodies  >1 publications with MTO1 and Nerve
 Blood Antibodies  >1 publications with MTO1 and Blood
 Eye Antibodies  >1 publications with MTO1 and Eye
 Mammary Gland Antibodies  >1 publications with MTO1 and Mammary Gland
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