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anti-MTOR antibody :: Rabbit anti-Human MTOR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044889
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTOR, Polyclonal Antibody

★Popular Item★
 Also Known As   

MTOR Antibody

 Product Synonym Names    Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammali; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
 Product Gene Name   

anti-MTOR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601231
 3D Structure    ModBase 3D Structure for P42345
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Serine/threonine-protein kinase mTOR protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1549 / sc-1550-R / sc-8319
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MTOR antibody

   Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).
 Applications Tested/Suitable for anti-MTOR antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-MTOR antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7044889 at dilution of 1:100
anti-MTOR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-MTOR antibody    Immunofluorescent analysis of Hela cells using MBS7044889 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-MTOR antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MTOR. It may not necessarily be applicable to this product.
 NCBI GI #    4826730
 NCBI GeneID    2475
 NCBI Accession #    NP_004949.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004958.3 [Other Products]
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 UniProt Primary Accession #    P42345 [Other Products]
 UniProt Secondary Accession #    Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3 [Other Products]
 UniProt Related Accession #    P42345 [Other Products]
 Molecular Weight    288,892 Da
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 NCBI Official Full Name    serine/threonine-protein kinase mTOR
 NCBI Official Synonym Full Names    mechanistic target of rapamycin
 NCBI Official Symbol    MTOR [Similar Products]
 NCBI Official Synonym Symbols   
SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase mTOR
 UniProt Protein Name    Serine/threonine-protein kinase mTOR
 UniProt Synonym Protein Names   
FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    MTOR [Similar Products]
 UniProt Synonym Gene Names    FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mTOR [Similar Products]
 UniProt Entry Name    MTOR_HUMAN
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 NCBI Summary for MTOR    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for MTOR    mTOR: an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779).

Protein type: Motility/polarity/chemotaxis; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Autophagy; Protein kinase, atypical; EC 2.7.11.1; ATYPICAL group; PIKK family; FRAP subfamily

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: cytoplasm; cytosol; endomembrane system; lysosomal membrane; lysosome; membrane; nucleoplasm; nucleus; PML body; TORC2 complex

Molecular Function: kinase activity; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell cycle arrest; cell growth; cellular response to nutrient levels; DNA repair; macroautophagy; negative regulation of autophagy; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein catabolic process; regulation of actin cytoskeleton organization and biogenesis; regulation of osteoclast differentiation; response to amino acid stimulus; response to stress; T cell costimulation; TOR signaling pathway

Disease: Smith-kingsmore Syndrome
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 Research Articles on MTOR    1. Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MTOR antibodyPathways associated with anti-MTOR antibody
 Reference Product  PubMed Publications
 EIF4EBP1 antibody  >633 publications with MTOR and EIF4EBP1
 AKT1 antibody  >535 publications with MTOR and AKT1
 RICTOR antibody  >474 publications with MTOR and RICTOR
 RHEB antibody  >345 publications with MTOR and RHEB
 RPTOR antibody  >237 publications with MTOR and RPTOR
 MLST8 antibody  >54 publications with MTOR and MLST8
 RPS6KB1 antibody  >51 publications with MTOR and RPS6KB1
 AKT1S1 antibody  >37 publications with MTOR and AKT1S1
 MAPKAP1 antibody  >31 publications with MTOR and MAPKAP1
 FKBP1A antibody  >6 publications with MTOR and FKBP1A
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
Diseases associated with anti-MTOR antibodyOrgans/Tissues associated with anti-MTOR antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1514 publications with MTOR and Adenocarcinoma
 Disease Models, Animal Antibodies  >1212 publications with MTOR and Disease Models, Animal
 Kidney Diseases Antibodies  >1155 publications with MTOR and Kidney Diseases
 Breast Neoplasms Antibodies  >1055 publications with MTOR and Breast Neoplasms
 Carcinoma, Renal Cell Antibodies  >857 publications with MTOR and Carcinoma, Renal Cell
 Cardiovascular Diseases Antibodies  >837 publications with MTOR and Cardiovascular Diseases
 Inflammation Antibodies  >813 publications with MTOR and Inflammation
 Lung Neoplasms Antibodies  >713 publications with MTOR and Lung Neoplasms
 Liver Diseases Antibodies  >664 publications with MTOR and Liver Diseases
 Neoplasms, Experimental Antibodies  >660 publications with MTOR and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2362 publications with MTOR and Blood
 Brain Antibodies  >1885 publications with MTOR and Brain
 Muscle Antibodies  >1839 publications with MTOR and Muscle
 Kidney Antibodies  >1759 publications with MTOR and Kidney
 Vascular Antibodies  >1625 publications with MTOR and Vascular
 Liver Antibodies  >1440 publications with MTOR and Liver
 Lung Antibodies  >1243 publications with MTOR and Lung
 Heart Antibodies  >822 publications with MTOR and Heart
 Bone Antibodies  >670 publications with MTOR and Bone
 Prostate Antibodies  >545 publications with MTOR and Prostate
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