NP_001287714.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,865 Da
NCBI Official Full Name
microsomal triglyceride transfer protein large subunit isoform 2
NCBI Official Synonym Full Names
microsomal triglyceride transfer protein
NCBI Official Synonym Symbols
NCBI Protein Information
microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein (large polypeptide, 88kDa)
UniProt Protein Name
Microsomal triglyceride transfer protein large subunit
UniProt Synonym Gene Names
UniProt Entry Name
MTP_HUMAN
NCBI Summary for MTTP
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
UniProt Comments for MTTP
MTTP: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: endoplasmic reticulum lumen; receptor complex
Molecular Function: lipid transporter activity; lipid binding
Biological Process: lipoprotein metabolic process; lipid metabolic process; lipid transport
Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
Research Articles on MTTP
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Products associated with anti-MTTP antibody
Pathways associated with anti-MTTP antibody
Diseases associated with anti-MTTP antibody
Organs/Tissues associated with anti-MTTP antibody
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