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anti-MUCP3 antibody :: Rabbit MUCP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534704
Western Blot (WB)
Unit / Price
0.1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUCP3, Polyclonal Antibody

 Also Known As   

MUCP3 antibody

 Product Synonym Names    Polyclonal MUCP3; Anti-MUCP3; MUCP3; Mitochondrial Uncoupling Protein-3; MUCP -3; MUCP 3
 Product Gene Name   

anti-MUCP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601665
 3D Structure    ModBase 3D Structure for P55916
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Dog, Mouse, Rat
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 Specificity    Murine
 Purity/Purification    MUCP3 antibody was purified by affinity chromatography.
 Form/Format    Affinity purified rabbit serum supplied in PBS with 1% BSA and 0.05% NaN3.
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 Biological Significance    The uncoupling proteins (UCPs) are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the phosphate and oxologutarate carriers and the ADP/ATP translocator.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    MUCP3 antibody was raised in rabbit using a sythentic peptide C R(295) A L M K V Q V L R E S P F(308) corresponding to residues 295-308 of the mouse and rat UCP-3 protein as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MUCP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MUCP3 antibody

   Affinity purified Rabbit polyclonal MUCP3 antibody
 Product Categories/Family for anti-MUCP3 antibody    Cell Biology ; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-MUCP3 antibody   

Western Blot (WB)

 Application Notes for anti-MUCP3 antibody    WB: 1 ug/ml
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 Western Blot (WB) of anti-MUCP3 antibody    Western blot detection of recombinant human UCP-3
anti-MUCP3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MUCP3. It may not necessarily be applicable to this product.
 NCBI GI #    13259546
 NCBI GeneID    7352
 NCBI Accession #    NP_073714.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022803.2 [Other Products]
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 UniProt Primary Accession #    P55916 [Other Products]
 UniProt Secondary Accession #    O60475; Q96HL3 [Other Products]
 UniProt Related Accession #    P55916 [Other Products]
 Molecular Weight    22,874 Da
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 NCBI Official Full Name    mitochondrial uncoupling protein 3 isoform UCP3S
 NCBI Official Synonym Full Names    uncoupling protein 3 (mitochondrial, proton carrier)
 NCBI Official Symbol    UCP3 [Similar Products]
 NCBI Official Synonym Symbols   
SLC25A9
[Similar Products]
 NCBI Protein Information    mitochondrial uncoupling protein 3
 UniProt Protein Name    Mitochondrial uncoupling protein 3
 UniProt Synonym Protein Names   
Solute carrier family 25 member 9
 UniProt Gene Name    UCP3 [Similar Products]
 UniProt Synonym Gene Names    SLC25A9; UCP 3 [Similar Products]
 UniProt Entry Name    UCP3_HUMAN
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 NCBI Summary for MUCP3    Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
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 UniProt Comments for MUCP3    UCP3: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. Defects in UCP3 may be involved in obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: protein binding; transporter activity; oxidative phosphorylation uncoupler activity

Biological Process: response to superoxide; response to glucocorticoid stimulus; respiratory gaseous exchange; fatty acid metabolic process; mitochondrial transport; cellular response to hormone stimulus; response to insulin stimulus; cellular metabolic process; proton transport; response to hypoxia; response to cold; response to activity; lipid metabolic process; response to nutrient; aging

Disease: Obesity
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 Research Articles on MUCP3    1. Studied the impact of SNPs in/near UCP3 and RPTOR on obesity-related traits.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MUCP3 antibodyPathways associated with anti-MUCP3 antibody
 Reference Product  PubMed Publications
 UCP2 antibody  >429 publications with MUCP3 and UCP2
 UCP1 antibody  >298 publications with MUCP3 and UCP1
 PPARG antibody  >46 publications with MUCP3 and PPARG
 SLC2A4 antibody  >18 publications with MUCP3 and SLC2A4
 INS antibody  >8 publications with MUCP3 and INS
 LEP antibody  >5 publications with MUCP3 and LEP
 PPARA antibody  >4 publications with MUCP3 and PPARA
 SP3 antibody  >1 publications with MUCP3 and SP3
 Products by Pathway  Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Mitochondrial Uncoupling Proteins Pathway antibodies  Mitochondrial Uncoupling Proteins Pathway Diagram
 Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
 The Fatty Acid Cycling Model Pathway antibodies  The Fatty Acid Cycling Model Pathway Diagram
 The Proton Buffering Model Pathway antibodies  The Proton Buffering Model Pathway Diagram
Diseases associated with anti-MUCP3 antibodyOrgans/Tissues associated with anti-MUCP3 antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >269 publications with MUCP3 and Obesity
 Diabetes Mellitus Antibodies  >87 publications with MUCP3 and Diabetes Mellitus
 Insulin Resistance Antibodies  >73 publications with MUCP3 and Insulin Resistance
 Weight Gain Antibodies  >60 publications with MUCP3 and Weight Gain
 Diabetes Mellitus, Type 2 Antibodies  >51 publications with MUCP3 and Diabetes Mellitus, Type 2
 Hyperinsulinism Antibodies  >48 publications with MUCP3 and Hyperinsulinism
 Fatty Liver Antibodies  >44 publications with MUCP3 and Fatty Liver
 Weight Loss Antibodies  >44 publications with MUCP3 and Weight Loss
 Mitochondrial Diseases Antibodies  >42 publications with MUCP3 and Mitochondrial Diseases
 Disease Models, Animal Antibodies  >36 publications with MUCP3 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >565 publications with MUCP3 and Muscle
 Connective Tissue Antibodies  >217 publications with MUCP3 and Connective Tissue
 Blood Antibodies  >194 publications with MUCP3 and Blood
 Heart Antibodies  >117 publications with MUCP3 and Heart
 Liver Antibodies  >88 publications with MUCP3 and Liver
 Brain Antibodies  >46 publications with MUCP3 and Brain
 Lung Antibodies  >17 publications with MUCP3 and Lung
 Vascular Antibodies  >15 publications with MUCP3 and Vascular
 Embryonic Tissue Antibodies  >6 publications with MUCP3 and Embryonic Tissue
 Intestine Antibodies  >3 publications with MUCP3 and Intestine
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