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anti-STXBP1 antibody :: Goat MUNC18/STXBP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420125
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUNC18/STXBP1, Polyclonal Antibody

 Also Known As   

Goat anti-MUNC18/STXBP1 (isoform a) Antibody

 Product Synonym Names    STXBP1; MUNC18-1; UNC18; hUNC18; syntaxin binding protein 1; Hunc18; rbSec1; syntaxin-binding protein 1; RP11-56D16.3; EIEE4; FLJ37475; RBSEC1; STXBP1 antibody; MUNC18-1 antibody; UNC18 antibody; hUNC18 antibody; syntaxin binding protein 1 antibody; Hunc18 antibody; rbSec1 antibody; syntaxin-binding protein 1 antibody; RP11-56D16.3 antibody; EIEE4 antibody; FLJ37475 antibody; RBSEC1 antibody; MUNC18 / STXBP1 (isoform a)
 Product Gene Name   

anti-STXBP1 antibody

[Similar Products]
 Product Synonym Gene Name    MUNC18 [Similar Products]
 Antibody/Peptide Pairs    MUNC18 / STXBP1 peptide (MBS425992) is used for blocking the activity of MUNC18/STXBP1 antibody (MBS420125)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SRVSFEDQAP TME
 OMIM    602926
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SRVSFEDQAPTME, from the C Terminus of the protein sequence according to NP_003156.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize isoform a (NP_003156.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-STXBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STXBP1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-STXBP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Brain cortex shows vesicular staining in neuronal bodies. Recommended concentration, 5-10ug/ml.
Western Blot: Approx 75kDa band observed in Human and Mouse Brain lysates (calculated MW of 68.7kDa according to NP_003156.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-STXBP1 antibody    (0.1ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-STXBP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STXBP1 antibody    (5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-STXBP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STXBP1. It may not necessarily be applicable to this product.
 NCBI GI #    4507297
 NCBI GeneID    6812
 NCBI Accession #    NP_003156.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003165.3 [Other Products]
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 UniProt Secondary Accession #    Q28208; Q62759; Q64320; Q96TG8; B1AM97 [Other Products]
 UniProt Related Accession #    P61764 [Other Products]
 Molecular Weight    68,736 Da
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 NCBI Official Full Name    syntaxin-binding protein 1 isoform a
 NCBI Official Synonym Full Names    syntaxin binding protein 1
 NCBI Official Symbol    STXBP1 [Similar Products]
 NCBI Official Synonym Symbols   
P67; NSEC1; UNC18; RBSEC1; MUNC18-1
[Similar Products]
 NCBI Protein Information    syntaxin-binding protein 1
 UniProt Protein Name    Syntaxin-binding protein 1
 UniProt Synonym Protein Names   
MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
 Protein Family    Syntaxin-binding protein
 UniProt Gene Name    STXBP1 [Similar Products]
 UniProt Synonym Gene Names    UNC18A; Unc18-1; Unc-18A [Similar Products]
 UniProt Entry Name    STXB1_HUMAN
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 NCBI Summary for STXBP1    This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
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 UniProt Comments for STXBP1    STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleoplasm; plasma membrane; protein complex; terminal button

Molecular Function: identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding

Biological Process: axon target recognition; glutamate secretion; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; protein stabilization; protein transport; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; vesicle docking during exocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 4
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 Research Articles on STXBP1    1. de novo mutations in early-onset epilepsy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STXBP1 antibodyPathways associated with anti-STXBP1 antibody
 Reference Product  PubMed Publications
 STX1A antibody  >27 publications with STXBP1 and STX1A
 SNAP25 antibody  >16 publications with STXBP1 and SNAP25
 VAMP2 antibody  >8 publications with STXBP1 and VAMP2
 SYTL4 antibody  >4 publications with STXBP1 and SYTL4
 STX1B antibody  >4 publications with STXBP1 and STX1B
 INS antibody  >2 publications with STXBP1 and INS
 STX3 antibody  >1 publications with STXBP1 and STX3
 STX2 antibody  >1 publications with STXBP1 and STX2
 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with anti-STXBP1 antibodyOrgans/Tissues associated with anti-STXBP1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >65 publications with STXBP1 and Nervous System Diseases
 Brain Diseases Antibodies  >61 publications with STXBP1 and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >13 publications with STXBP1 and Neurobehavioral Manifestations
 Epilepsies, Myoclonic Antibodies  >9 publications with STXBP1 and Epilepsies, Myoclonic
 Congenital Abnormalities Antibodies  >6 publications with STXBP1 and Congenital Abnormalities
 Cognition Disorders Antibodies  >3 publications with STXBP1 and Cognition Disorders
 Inflammation Antibodies  >3 publications with STXBP1 and Inflammation
 Learning Disorders Antibodies  >2 publications with STXBP1 and Learning Disorders
 Memory Disorders Antibodies  >2 publications with STXBP1 and Memory Disorders
 Nervous System Malformations Antibodies  >2 publications with STXBP1 and Nervous System Malformations
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >89 publications with STXBP1 and Brain
 Nerve Antibodies  >70 publications with STXBP1 and Nerve
 Embryonic Tissue Antibodies  >11 publications with STXBP1 and Embryonic Tissue
 Muscle Antibodies  >10 publications with STXBP1 and Muscle
 Pancreas Antibodies  >9 publications with STXBP1 and Pancreas
 Eye Antibodies  >6 publications with STXBP1 and Eye
 Kidney Antibodies  >3 publications with STXBP1 and Kidney
 Ovary Antibodies  >3 publications with STXBP1 and Ovary
 Testis Antibodies  >3 publications with STXBP1 and Testis
 Vascular Antibodies  >3 publications with STXBP1 and Vascular
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