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anti-MUSK antibody :: Rabbit anti-Human, mouse MUSK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205728
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUSK, Polyclonal Antibody

★Popular Item★
 Also Known As   

MUSK Antibody

 Product Synonym Names    Muscle; skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor; MUSK
 Product Gene Name   

anti-MUSK antibody

[Similar Products]
 Antibody/Peptide Pairs    MUSK peptide (MBS9227138) is used for blocking the activity of MUSK antibody (MBS9205728)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    208150
 3D Structure    ModBase 3D Structure for O15146
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB14743
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This MUSK antibody is generated from rabbits immunized with human MUSK recombinant protein.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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 Antigen Type    Recombinant Protein
 Antigen Source    HUMAN
 Function    Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle.Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks.For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-MUSK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MUSK antibody

   MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation. MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.
 Product Categories/Family for anti-MUSK antibody    Signal Transduction
 Applications Tested/Suitable for anti-MUSK antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-MUSK antibody    WB~~1:1000
FC~~1:10~50
IF~~1:10~50
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 Western Blot (WB) of anti-MUSK antibody    Western blot analysis of anti-MUSK Pab in mouse kidney tissue lysates (35ug/lane). MUSK(arrow) was detected using the purified Pab.
anti-MUSK antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-MUSK antibody    MUSK Antibody flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-MUSK antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunofluorescence (IF) of anti-MUSK antibody    Confocal immunofluorescent analysis of MUSK Antibody with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
anti-MUSK antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MUSK. It may not necessarily be applicable to this product.
 NCBI GI #    261878455
 NCBI GeneID    4593
 NCBI Accession #    NP_001159752.1 [Other Products]
 NCBI Related Accession #    NP_001159753.1; NP_005583.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166280.1 [Other Products]
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 UniProt Primary Accession #    O15146 [Other Products]
 UniProt Secondary Accession #    Q32MJ8; Q32MJ9; Q5VZW7; Q5VZW8 [Other Products]
 UniProt Related Accession #    O15146 [Other Products]
 Molecular Weight    97056
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 NCBI Official Full Name    muscle, skeletal receptor tyrosine-protein kinase isoform 2
 NCBI Official Synonym Full Names    muscle, skeletal, receptor tyrosine kinase
 NCBI Official Symbol    MUSK [Similar Products]
 NCBI Official Synonym Symbols   
CMS9
[Similar Products]
 NCBI Protein Information    muscle, skeletal receptor tyrosine-protein kinase
 UniProt Protein Name    Muscle, skeletal receptor tyrosine-protein kinase
 UniProt Synonym Protein Names   
Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor
 Protein Family    Muskelin
 UniProt Gene Name    MUSK [Similar Products]
 UniProt Synonym Gene Names    MuSK; Muscle-specific kinase receptor [Similar Products]
 UniProt Entry Name    MUSK_HUMAN
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 NCBI Summary for MUSK    This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
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 UniProt Comments for MUSK    MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.

Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Musk family

Chromosomal Location of Human Ortholog: 9q31.3-q32

Cellular Component: postsynaptic membrane; integral to plasma membrane; cell junction; neuromuscular junction; receptor complex

Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; multicellular organismal development; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; neuromuscular junction development; memory; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency; Fetal Akinesia Deformation Sequence
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Product References and Citations for anti-MUSK antibody

   Blume-Jensen P, et al. Nature 2001. 411: 355.
Cantrell D, J. Cell Sci. 2001. 114: 1439.
Jhiang S Oncogene 2000. 19: 5590.
Manning G, et al. Science 2002. 298: 1912.
Moller, D, et al. Am. J. Physiol. 1994. 266: C351-C359.
Robertson, S. et al. Trends Genet. 2000. 16: 368.
Robinson D, et al. Oncogene 2000. 19: 5548.
Van der Ven, P, et al. Hum. Molec. Genet. 1993. 2: 1889.
Vanhaesebroeck, B, et al. Biochem. J. 2000. 346: 561.
Van Weering D, et al. Recent Results Cancer Res. 1998. 154: 271.
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 Research Articles on MUSK    1. MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MUSK antibodyDiseases associated with anti-MUSK antibody
 Reference Product  PubMed Publications
 LRP4 antibody  >74 publications with MUSK and LRP4
 DOK7 antibody  >34 publications with MUSK and DOK7
 COLQ antibody  >25 publications with MUSK and COLQ
 AGRN antibody  >7 publications with MUSK and AGRN
 RAPSN antibody  >6 publications with MUSK and RAPSN
 CHRNG antibody  >3 publications with MUSK and CHRNG
 SYNE1 antibody  >2 publications with MUSK and SYNE1
 CHRNB1 antibody  >2 publications with MUSK and CHRNB1
 PDZRN3 antibody  >1 publications with MUSK and PDZRN3
 DVL1 antibody  >1 publications with MUSK and DVL1
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >428 publications with MUSK and Immune System Diseases
 Myasthenia Gravis Antibodies  >388 publications with MUSK and Myasthenia Gravis
 Disease Models, Animal Antibodies  >105 publications with MUSK and Disease Models, Animal
 Atrophy Antibodies  >51 publications with MUSK and Atrophy
 Inflammation Antibodies  >42 publications with MUSK and Inflammation
 Fibrosis Antibodies  >37 publications with MUSK and Fibrosis
 Vascular Diseases Antibodies  >33 publications with MUSK and Vascular Diseases
 Necrosis Antibodies  >23 publications with MUSK and Necrosis
 Poisoning Antibodies  >22 publications with MUSK and Poisoning
 Liver Diseases Antibodies  >21 publications with MUSK and Liver Diseases
Organs/Tissues associated with anti-MUSK antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >656 publications with MUSK and Muscle
 Lung Antibodies  >213 publications with MUSK and Lung
 Brain Antibodies  >192 publications with MUSK and Brain
 Eye Antibodies  >48 publications with MUSK and Eye
 Connective Tissue Antibodies  >46 publications with MUSK and Connective Tissue
 Embryonic Tissue Antibodies  >39 publications with MUSK and Embryonic Tissue
 Testis Antibodies  >34 publications with MUSK and Testis
 Mouth Antibodies  >33 publications with MUSK and Mouth
 Uncharacterized Tissue Antibodies  >1 publications with MUSK and Uncharacterized Tissue
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