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anti-MVP antibody :: Rabbit anti-Human MVP / LRP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241036
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MVP / LRP, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human MVP / LRP

 Product Synonym Names    Anti-MVP / LRP Antibody (aa878-893) IHC-plus; MVP; Major vault protein; VAULT1; LRP; Human MVP; LRP
 Product Gene Name   

anti-MVP antibody

[Similar Products]
 Product Synonym Gene Name    LRP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605088
 3D Structure    ModBase 3D Structure for Q14764
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Amino acids 878-893 of human MVP
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human MVP.
 Immunogen Type    Synthetic peptide
 Immunogen    MVP / LRP antibody was raised against synthetic peptide from human MVP.
 Antigen Modification    aa878-893
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-MVP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MVP antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-MVP antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-MVP antibody    Anti-MVP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MVP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.
 NCBI GI #    19913410
 NCBI GeneID    9961
 NCBI Accession #    NP_059447.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017458.3 [Other Products]
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 UniProt Primary Accession #    Q14764 [Other Products]
 UniProt Secondary Accession #    Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1 [Other Products]
 UniProt Related Accession #    Q14764 [Other Products]
 Molecular Weight    99,327 Da
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 NCBI Official Full Name    major vault protein isoform 1
 NCBI Official Synonym Full Names    major vault protein
 NCBI Official Symbol    MVP [Similar Products]
 NCBI Official Synonym Symbols   
LRP; VAULT1
[Similar Products]
 NCBI Protein Information    major vault protein; lung resistance-related protein
 UniProt Protein Name    Major vault protein
 UniProt Synonym Protein Names   
Lung resistance-related protein
 Protein Family    Hyperpolarization-activated voltage-gated potassium channel
 UniProt Gene Name    MVP [Similar Products]
 UniProt Synonym Gene Names    LRP; MVP [Similar Products]
 UniProt Entry Name    MVP_HUMAN
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 NCBI Summary for MVP    This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for MVP    MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; ribonucleoprotein complex; nucleus

Molecular Function: protein binding; protein phosphatase binding; protein kinase binding

Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation
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 Research Articles on MVP    1. Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR/PI3K-mediated migration and survival pathways in human glioblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MVP antibodyDiseases associated with anti-MVP antibody
 Reference Product  PubMed Publications
 ABCB1 antibody  >45 publications with MVP and ABCB1
 ABCC1 antibody  >9 publications with MVP and ABCC1
 ABCC3 antibody  >6 publications with MVP and ABCC3
 PTEN antibody  >6 publications with MVP and PTEN
 STAT1 antibody  >2 publications with MVP and STAT1
 PTPN11 antibody  >1 publications with MVP and PTPN11
 YPEL4 antibody  >1 publications with MVP and YPEL4
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >765 publications with MVP and Heart Diseases
 Nervous System Diseases Antibodies  >158 publications with MVP and Nervous System Diseases
 Pain Antibodies  >82 publications with MVP and Pain
 Brain Diseases Antibodies  >79 publications with MVP and Brain Diseases
 Adenocarcinoma Antibodies  >44 publications with MVP and Adenocarcinoma
 Disease Models, Animal Antibodies  >32 publications with MVP and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >32 publications with MVP and Neoplasm Metastasis
 Hypertension Antibodies  >31 publications with MVP and Hypertension
 Fibrosis Antibodies  >30 publications with MVP and Fibrosis
 Hypertrophy Antibodies  >29 publications with MVP and Hypertrophy
Organs/Tissues associated with anti-MVP antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >556 publications with MVP and Heart
 Blood Antibodies  >270 publications with MVP and Blood
 Lung Antibodies  >215 publications with MVP and Lung
 Vascular Antibodies  >111 publications with MVP and Vascular
 Brain Antibodies  >81 publications with MVP and Brain
 Muscle Antibodies  >64 publications with MVP and Muscle
 Bone Antibodies  >61 publications with MVP and Bone
 Connective Tissue Antibodies  >45 publications with MVP and Connective Tissue
 Liver Antibodies  >36 publications with MVP and Liver
 Bladder Antibodies  >32 publications with MVP and Bladder
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