NP_000247.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,703 Da
NCBI Official Full Name
myosin-binding protein C, cardiac-type
NCBI Official Synonym Full Names
myosin binding protein C, cardiac
NCBI Official Synonym Symbols
FHC; CMH4; CMD1MM; LVNC10; MYBP-C [Similar Products]
NCBI Protein Information
myosin-binding protein C, cardiac-type
UniProt Protein Name
Myosin-binding protein C, cardiac-type
UniProt Synonym Protein Names
C-protein, cardiac muscle isoform
UniProt Synonym Gene Names
NCBI Summary for MYBPC3
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYBPC3
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Research Articles on MYBPC3
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Products associated with anti-MYBPC3 antibody
Pathways associated with anti-MYBPC3 antibody
Diseases associated with anti-MYBPC3 antibody
Disease Name |
Pubmed Publications |
Heart Diseases Antibodies |
>168 publications with MYBPC3 and Heart Diseases |
Cardiomyopathies Antibodies |
>159 publications with MYBPC3 and Cardiomyopathies |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>78 publications with MYBPC3 and Cardiomyopathy, Hypertrophic, Familial |
Hypertrophy Antibodies |
>65 publications with MYBPC3 and Hypertrophy |
Death, Sudden, Cardiac Antibodies |
>42 publications with MYBPC3 and Death, Sudden, Cardiac |
Cardiomyopathy, Familial Hypertrophic, 4 Antibodies |
>25 publications with MYBPC3 and Cardiomyopathy, Familial Hypertrophic, 4 |
Cardiomyopathy, Dilated Antibodies |
>24 publications with MYBPC3 and Cardiomyopathy, Dilated |
Congenital Abnormalities Antibodies |
>7 publications with MYBPC3 and Congenital Abnormalities |
Disease Models, Animal Antibodies |
>7 publications with MYBPC3 and Disease Models, Animal |
Heart Defects, Congenital Antibodies |
>5 publications with MYBPC3 and Heart Defects, Congenital |
Organs/Tissues associated with anti-MYBPC3 antibody
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