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anti-MYC antibody :: Rabbit anti-Human MYC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7003538
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYC, Polyclonal Antibody

★Popular Item★
 Also Known As   

MYC Antibody

 Product Synonym Names    Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; MYC; BHLHE39
 Product Gene Name   

anti-MYC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113970
 3D Structure    ModBase 3D Structure for P01106
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Myc proto-oncogene protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-789 / sc-788 / sc-764
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MYC antibody

   Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
 Applications Tested/Suitable for anti-MYC antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-MYC antibody    Western Blot
Positive WB detected in: Mouse kidney tissue,Mouse heart tissue
All lanes: MYC antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49 KDa
Observed band size: 49 KDa

anti-MYC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MYC antibody    Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7003538 at dilution of 1:100
anti-MYC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
 NCBI GI #    71774083
 NCBI GeneID    4609
 NCBI Accession #    NP_002458.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002467.4 [Other Products]
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 UniProt Primary Accession #    P01106 [Other Products]
 UniProt Secondary Accession #    P01107; Q14026; A8WFE7 [Other Products]
 UniProt Related Accession #    P01106 [Other Products]
 Molecular Weight    50,565 Da
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 NCBI Official Full Name    myc proto-oncogene protein
 NCBI Official Synonym Full Names    v-myc avian myelocytomatosis viral oncogene homolog
 NCBI Official Symbol    MYC [Similar Products]
 NCBI Official Synonym Symbols   
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
 NCBI Protein Information    myc proto-oncogene protein
 UniProt Protein Name    Myc proto-oncogene protein
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
 Protein Family    Mycosin
 UniProt Gene Name    MYC [Similar Products]
 UniProt Synonym Gene Names    BHLHE39; bHLHe39 [Similar Products]
 UniProt Entry Name    MYC_HUMAN
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 NCBI Summary for MYC    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYC    Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: Nucleolus; Oncoprotein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein complex binding; protein dimerization activity; transcription factor activity; transcription factor binding

Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; energy reserve metabolic process; gene expression; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; oxygen transport; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; regulation of telomere maintenance; response to DNA damage stimulus; response to drug; response to gamma radiation; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma
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 Research Articles on MYC    1. Demonstrate an association between nuclear C-MYC immunostaining and TMPRSS2-ERG status in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYC antibodyPathways associated with anti-MYC antibody
 Reference Product  PubMed Publications
 MAX antibody  >1047 publications with MYC and MAX
 CDKN2A antibody  >483 publications with MYC and CDKN2A
 FBXW7 antibody  >114 publications with MYC and FBXW7
 SKP2 antibody  >97 publications with MYC and SKP2
 ZBTB17 antibody  >51 publications with MYC and ZBTB17
 EP300 antibody  >23 publications with MYC and EP300
 KAT5 antibody  >15 publications with MYC and KAT5
 PFDN5 antibody  >14 publications with MYC and PFDN5
 GSK3B antibody  >7 publications with MYC and GSK3B
 SUPT3H antibody  >4 publications with MYC and SUPT3H
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway antibodies  Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-MYC antibodyOrgans/Tissues associated with anti-MYC antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4106 publications with MYC and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2704 publications with MYC and Cell Transformation, Neoplastic
 Neuroectodermal Tumors Antibodies  >2309 publications with MYC and Neuroectodermal Tumors
 Neuroblastoma Antibodies  >1568 publications with MYC and Neuroblastoma
 Breast Neoplasms Antibodies  >1552 publications with MYC and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1459 publications with MYC and Neoplasms, Experimental
 Disease Progression Antibodies  >1193 publications with MYC and Disease Progression
 Liver Neoplasms Antibodies  >1167 publications with MYC and Liver Neoplasms
 Liver Diseases Antibodies  >1152 publications with MYC and Liver Diseases
 Burkitt Lymphoma Antibodies  >1004 publications with MYC and Burkitt Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3794 publications with MYC and Blood
 Liver Antibodies  >2112 publications with MYC and Liver
 Lung Antibodies  >1548 publications with MYC and Lung
 Bone Antibodies  >1471 publications with MYC and Bone
 Brain Antibodies  >1310 publications with MYC and Brain
 Muscle Antibodies  >1192 publications with MYC and Muscle
 Bone Marrow Antibodies  >1023 publications with MYC and Bone Marrow
 Vascular Antibodies  >989 publications with MYC and Vascular
 Kidney Antibodies  >882 publications with MYC and Kidney
 Prostate Antibodies  >816 publications with MYC and Prostate
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