NC_000018.9
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,983 Da
NCBI Official Full Name
Homo sapiens chromosome 18, GRCh37.p13 Primary Assembly
NCBI Official Synonym Full Names
myosin VB
NCBI Protein Information
unconventional myosin-Vb; MYO5B variant protein
UniProt Protein Name
Unconventional myosin-Vb
UniProt Synonym Gene Names
UniProt Entry Name
MYO5B_HUMAN
NCBI Summary for MYO5B
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
UniProt Comments for MYO5B
MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: recycling endosome; protein complex; cytoplasmic vesicle membrane; apical cortex; myosin complex
Molecular Function: microfilament motor activity; calmodulin binding; protein binding; actin binding; ATP binding; Rab GTPase binding
Biological Process: vesicle-mediated transport; protein transport; metabolic process; water transport; renal water homeostasis; transmembrane transport; endosome localization
Disease: Diarrhea 2, With Microvillus Atrophy
Research Articles on MYO5B
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Products associated with anti-MYO5B antibody
Pathways associated with anti-MYO5B antibody
Diseases associated with anti-MYO5B antibody
Organs/Tissues associated with anti-MYO5B antibody
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