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anti-MYO5B antibody :: Rabbit anti-Human, Mouse MYO5B / Myosin VB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241891
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYO5B / Myosin VB, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MYO5B / Myosin VB

 Product Synonym Names    Anti-MYO5B / Myosin VB Antibody (N-Terminus) IHC-plus; MYO5B; KIAA1119; Myosin VB; Myosin-Vb; Unconventional myosin-Vb; MYO5B variant protein; Human MYO5B; Myosin VB
 Product Gene Name   

anti-MYO5B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 606540
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Synthetic peptide corresponding to N-terminal residues of human Myosin-5B (Myosin Vb).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human MYO5B.
 Immunogen Type    Synthetic peptide
 Immunogen    MYO5B / Myosin VB antibody was raised against synthetic peptide from human MYO5B.
 Antigen Modification    N-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-MYO5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYO5B antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MYO5B antibody    ELISA (1 ug/ml), IHC-P (2.5 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MYO5B antibody    Anti-MYO5B antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-MYO5B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MYO5B. It may not necessarily be applicable to this product.
 NCBI GI #    224589809
 NCBI GeneID    4645
 NCBI Accession #    NC_000018.9 [Other Products]
 NCBI GenBank Nucleotide #    NC_000018.9 [Other Products]
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 UniProt Secondary Accession #    Q0P656; Q9H6Y6; B0I1R3 [Other Products]
 UniProt Related Accession #    Q9ULV0 [Other Products]
 Molecular Weight    47,983 Da
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 NCBI Official Full Name    Homo sapiens chromosome 18, GRCh37.p13 Primary Assembly
 NCBI Official Synonym Full Names    myosin VB
 NCBI Official Symbol    MYO5B [Similar Products]
 NCBI Protein Information    unconventional myosin-Vb; MYO5B variant protein
 UniProt Protein Name    Unconventional myosin-Vb
 Protein Family    Unconventional myosin
 UniProt Gene Name    MYO5B [Similar Products]
 UniProt Synonym Gene Names    KIAA1119 [Similar Products]
 UniProt Entry Name    MYO5B_HUMAN
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 NCBI Summary for MYO5B    The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
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 UniProt Comments for MYO5B    MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: recycling endosome; protein complex; cytoplasmic vesicle membrane; apical cortex; myosin complex

Molecular Function: microfilament motor activity; calmodulin binding; protein binding; actin binding; ATP binding; Rab GTPase binding

Biological Process: vesicle-mediated transport; protein transport; metabolic process; water transport; renal water homeostasis; transmembrane transport; endosome localization

Disease: Diarrhea 2, With Microvillus Atrophy
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 Research Articles on MYO5B    1. Part of the machinery for ezrin activation depends on recycling endosomes controlled by myosin Vb and Rab11a.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYO5B antibodyPathways associated with anti-MYO5B antibody
 Reference Product  PubMed Publications
 RAB11A antibody  >20 publications with MYO5B and RAB11A
 RAB8A antibody  >7 publications with MYO5B and RAB8A
 RAB25 antibody  >3 publications with MYO5B and RAB25
 CXCR2 antibody  >1 publications with MYO5B and CXCR2
 CFTR antibody  >1 publications with MYO5B and CFTR
 AQP2 antibody  >1 publications with MYO5B and AQP2
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
Diseases associated with anti-MYO5B antibodyOrgans/Tissues associated with anti-MYO5B antibody
 Disease Name  Pubmed Publications
 Microvillus inclusion disease Antibodies  >19 publications with MYO5B and Microvillus inclusion disease
 Nervous System Diseases Antibodies  >14 publications with MYO5B and Nervous System Diseases
 Intestinal Diseases Antibodies  >14 publications with MYO5B and Intestinal Diseases
 Diarrhea Antibodies  >14 publications with MYO5B and Diarrhea
 Brain Diseases Antibodies  >12 publications with MYO5B and Brain Diseases
 Metabolism, Inborn Errors Antibodies  >12 publications with MYO5B and Metabolism, Inborn Errors
 Fibrosis Antibodies  >2 publications with MYO5B and Fibrosis
 Heart Diseases Antibodies  >1 publications with MYO5B and Heart Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MYO5B and Neoplasm Metastasis
 Liver Diseases Antibodies  >1 publications with MYO5B and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with MYO5B and Brain
 Intestine Antibodies  >12 publications with MYO5B and Intestine
 Liver Antibodies  >5 publications with MYO5B and Liver
 Kidney Antibodies  >4 publications with MYO5B and Kidney
 Muscle Antibodies  >3 publications with MYO5B and Muscle
 Stomach Antibodies  >3 publications with MYO5B and Stomach
 Bladder Antibodies  >2 publications with MYO5B and Bladder
 Eye Antibodies  >2 publications with MYO5B and Eye
 Lung Antibodies  >1 publications with MYO5B and Lung
 Ascites Antibodies  >1 publications with MYO5B and Ascites
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