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anti-MYO7A antibody :: Rabbit MYO7A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821898
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYO7A, Polyclonal Antibody

 Also Known As   

Anti-MYO7A Antibody

 Product Synonym Names    USH1B; Unconventional myosin-VIIa
 Product Gene Name   

anti-MYO7A antibody

[Similar Products]
 Antibody/Peptide Pairs    MYO7A peptide (MBS823432) is used for blocking the activity of MYO7A antibody (MBS821898)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 601317
 3D Structure    ModBase 3D Structure for Q13402
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Pig
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 Specificity    Recognizes endogenous levels of MYO7A protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MYO7A. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MYO7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MYO7A antibody

   Rabbit polyclonal antibody to MYO7A
 Applications Tested/Suitable for anti-MYO7A antibody   

Western Blot (WB)

 Application Notes for anti-MYO7A antibody    WB (1/500 - 1/1000)
Western blot analysis of MYO7A expression in SKOVCAR (A), HEK293T (B) whole cell lysates.
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 Western Blot (WB) of anti-MYO7A antibody    anti-MYO7A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MYO7A. It may not necessarily be applicable to this product.
 NCBI GI #    189083798
 NCBI GeneID    4647
 NCBI Accession #    NP_000251.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000260.3 [Other Products]
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 UniProt Primary Accession #    Q13402 [Other Products]
 UniProt Secondary Accession #    P78427; Q13321; Q14785; Q92821; Q92822; B9A011; F8VUN5 [Other Products]
 UniProt Related Accession #    Q13402 [Other Products]
 Molecular Weight    249,165 Da
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 NCBI Official Full Name    unconventional myosin-VIIa isoform 1
 NCBI Official Synonym Full Names    myosin VIIA
 NCBI Official Symbol    MYO7A [Similar Products]
 NCBI Official Synonym Symbols   
DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA
[Similar Products]
 NCBI Protein Information    unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
 UniProt Protein Name    Unconventional myosin-VIIa
 Protein Family    Unconventional myosin
 UniProt Gene Name    MYO7A [Similar Products]
 UniProt Synonym Gene Names    USH1B [Similar Products]
 UniProt Entry Name    MYO7A_HUMAN
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 NCBI Summary for MYO7A    This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYO7A    MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: stereocilium; photoreceptor inner segment; photoreceptor outer segment; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium

Molecular Function: actin filament binding; microfilament motor activity; calmodulin binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; ADP binding; actin-dependent ATPase activity; ATP binding

Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; lysosome organization and biogenesis; actin filament-based movement; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis

Disease: Deafness, Autosomal Recessive 2; Deafness, Autosomal Dominant 11; Usher Syndrome, Type I
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 Research Articles on MYO7A    1. The MYO7A gene is responsible for two distinct diseases and gives evidence that the p.P1887L mutation in a homozygous state may be responsible for nonsyndromic hearing loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYO7A antibodyPathways associated with anti-MYO7A antibody
 Reference Product  PubMed Publications
 CDH23 antibody  >36 publications with MYO7A and CDH23
 USH1C antibody  >28 publications with MYO7A and USH1C
 PCDH15 antibody  >26 publications with MYO7A and PCDH15
 USH1G antibody  >14 publications with MYO7A and USH1G
 DFNB31 antibody  >5 publications with MYO7A and DFNB31
 RAB27A antibody  >2 publications with MYO7A and RAB27A
 YY1 antibody  >1 publications with MYO7A and YY1
 VEZT antibody  >1 publications with MYO7A and VEZT
 MYRIP antibody  >1 publications with MYO7A and MYRIP
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
Diseases associated with anti-MYO7A antibodyOrgans/Tissues associated with anti-MYO7A antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >66 publications with MYO7A and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >58 publications with MYO7A and Abnormalities, Multiple
 Usher Syndromes Antibodies  >56 publications with MYO7A and Usher Syndromes
 Disease Models, Animal Antibodies  >18 publications with MYO7A and Disease Models, Animal
 Usher syndrome, type 1B Antibodies  >6 publications with MYO7A and Usher syndrome, type 1B
 Kidney Diseases Antibodies  >1 publications with MYO7A and Kidney Diseases
 Inflammation Antibodies  >1 publications with MYO7A and Inflammation
 Deafness, Autosomal Dominant 11 Antibodies  >1 publications with MYO7A and Deafness, Autosomal Dominant 11
 Melanoma Antibodies  >1 publications with MYO7A and Melanoma
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >41 publications with MYO7A and Eye
 Nerve Antibodies  >13 publications with MYO7A and Nerve
 Bone Antibodies  >5 publications with MYO7A and Bone
 Brain Antibodies  >4 publications with MYO7A and Brain
 Embryonic Tissue Antibodies  >3 publications with MYO7A and Embryonic Tissue
 Ovary Antibodies  >1 publications with MYO7A and Ovary
 Adipose Tissue Antibodies  >1 publications with MYO7A and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with MYO7A and Connective Tissue
 Intestine Antibodies  >1 publications with MYO7A and Intestine
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