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anti-MYOT antibody :: Rabbit anti-Human, Mouse MYOT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493502
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYOT, Polyclonal Antibody

★Popular Item★
 Also Known As   

MYOT Antibody

 Product Synonym Names    57 kDa cytoskeletal protein; Myofibrillar titin-like Ig domains protein; Titin immunoglobulin domain protein; MYOT; TTID
 Product Gene Name   

anti-MYOT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    159000
 3D Structure    ModBase 3D Structure for Q9UBF9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Myotilin protein (443-498aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15235 / sc-15237
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MYOT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MYOT antibody

   Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.
 Applications Tested/Suitable for anti-MYOT antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MYOT antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-MYOT antibody    Western blot
All lanes: MYOT antibody at 2ug/ml
Lane 1:293T whole cell lysate
Lane 2:HepG2 whole cell lysate
Lane 3:mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 56,36 kDa
Observed band size: 55 kDa

anti-MYOT antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MYOT antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS1493502 at dilution 1:100
anti-MYOT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MYOT. It may not necessarily be applicable to this product.
 NCBI GI #    209693444
 NCBI GeneID    9499
 NCBI Accession #    NP_001129412.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135940.1 [Other Products]
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 UniProt Primary Accession #    Q9UBF9 [Other Products]
 UniProt Secondary Accession #    A0A4R6; B4DT79 [Other Products]
 UniProt Related Accession #    Q9UBF9 [Other Products]
 Molecular Weight    35,147 Da
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 NCBI Official Full Name    myotilin isoform b
 NCBI Official Synonym Full Names    myotilin
 NCBI Official Symbol    MYOT [Similar Products]
 NCBI Official Synonym Symbols   
MFM3; TTID; TTOD; LGMD1; LGMD1A
[Similar Products]
 NCBI Protein Information    myotilin
 UniProt Protein Name    Myotilin
 UniProt Synonym Protein Names   
57 kDa cytoskeletal protein; Myofibrillar titin-like Ig domains protein; Titin immunoglobulin domain protein
 Protein Family    Myotilin
 UniProt Gene Name    MYOT [Similar Products]
 UniProt Synonym Gene Names    TTID [Similar Products]
 UniProt Entry Name    MYOTI_HUMAN
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 NCBI Summary for MYOT    This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[provided by RefSeq, Oct 2008]
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 UniProt Comments for MYOT    MYOT: Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. Defects in MYOT are the cause of limb-girdle muscular dystrophy type 1A (LGMD1A). LGMD1A is an autosomal dominant degenerative myopathy with onset within a mean age of 28 years. LGMD1A is characterized by progressive skeletal muscle weakness of the hip and shoulder girdles, later progressing to include distal weakness, as well as a distinctive dysarthric pattern of speech. Affected muscle exhibits disorganization and streaming of the Z-line. Defects in MYOT are the cause of myopathy myofibrillar type 3 (MFM3). A neuromuscular disorder characterized by progressive skeletal muscle weakness greater distally than proximally, tight heel cords, hyporeflexia, cardiomyopathy and peripheral neuropathy in some patients. Affected muscle exhibits disorganization and streaming of the Z-line, presence of large hyaline structures, excessive accumulation of myotilin and other ectopically expressed proteins and prominent congophilic deposits. Defects in MYOT are the cause of spheroid body myopathy (SBM). SBM is an autosomal dominant form of myofibrillar myopathy (MFM), characterized by slowly progressing proximal muscle weakness and dysarthric nasal speech. There is no evidence of cardiomyopathy. Muscle biopsy shows spheroid bodies within the type I muscle fibers. Belongs to the myotilin/palladin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: actin cytoskeleton; sarcolemma; Z disc

Molecular Function: actin binding; alpha-actinin binding; protein binding; structural constituent of muscle

Biological Process: muscle contraction

Disease: Muscular Dystrophy, Limb-girdle, Type 1a; Myopathy, Myofibrillar, 3; Myopathy, Spheroid Body
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 Research Articles on MYOT    1. Describe the first homozygous mutation in the myotilin gene leading to a novel, autosomal recessive subtype of myofibrillar myopathy (MFM).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYOT antibodyDiseases associated with anti-MYOT antibody
 Reference Product  PubMed Publications
 LDB3 antibody  >12 publications with MYOT and LDB3
 FLNC antibody  >12 publications with MYOT and FLNC
 LMNA antibody  >1 publications with MYOT and LMNA
 Disease Name  Pubmed Publications
 Muscle Weakness Antibodies  >19 publications with MYOT and Muscle Weakness
 Myotilinopathy Antibodies  >16 publications with MYOT and Myotilinopathy
 MYOPATHY, SPHEROID BODY Antibodies  >6 publications with MYOT and MYOPATHY, SPHEROID BODY
 Cardiomyopathies Antibodies  >6 publications with MYOT and Cardiomyopathies
 Disease Models, Animal Antibodies  >3 publications with MYOT and Disease Models, Animal
 Cardiomegaly Antibodies  >2 publications with MYOT and Cardiomegaly
 Abnormalities, Multiple Antibodies  >2 publications with MYOT and Abnormalities, Multiple
 Chromosome Aberrations Antibodies  >2 publications with MYOT and Chromosome Aberrations
 Heart Defects, Congenital Antibodies  >1 publications with MYOT and Heart Defects, Congenital
 Necrosis Antibodies  >1 publications with MYOT and Necrosis
Organs/Tissues associated with anti-MYOT antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >74 publications with MYOT and Muscle
 Heart Antibodies  >9 publications with MYOT and Heart
 Nerve Antibodies  >7 publications with MYOT and Nerve
 Brain Antibodies  >6 publications with MYOT and Brain
 Embryonic Tissue Antibodies  >3 publications with MYOT and Embryonic Tissue
 Lung Antibodies  >2 publications with MYOT and Lung
 Liver Antibodies  >2 publications with MYOT and Liver
 Larynx Antibodies  >1 publications with MYOT and Larynx
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