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anti-CSF1R antibody :: Sheep anti-Mouse Macrophage Colony Stimulating Factor Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS614988 anti-CSF1R antibody
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage Colony Stimulating Factor Receptor (CSF1R), Polyclonal Antibody

 Also Known As   

Macrophage Colony Stimulating Factor Receptor (M-CSFR, CSF-1)

 Product Synonym Names    Anti -Macrophage Colony Stimulating Factor Receptor (M-CSFR, CSF-1)
 Product Gene Name   

anti-CSF1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (149432854..149492935, complement). Location: 5q32
 OMIM    164770
 3D Structure    ModBase 3D Structure for P07333
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse M-CSF R. Species Crossreactivity: ~40% cross-reactivity with recombinant human M-CSF R.
 Purity/Purification    Affinity Purified
Purified by mouse M-CSF R affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 500ul sterile 40-50% glycerol, PBS.
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 Immunogen    NS0-derived recombinant mouse Macrophage Colony Stimulating Factor Receptor extracellular domain
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CSF1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CSF1R antibody

   Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. MCSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.. Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Tyrosine 723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated tyrosine 723 binds the p85 subunit of PI3 kinase as well as PLC-gamma2. Phosphorylation of Tyr809 provides a docking site for Shc.. Overactivation of this receptor can lead to a malignant phenotype in various cell systems. The activated MCSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma and breast cancer.
 Product Categories/Family for anti-CSF1R antibody    Antibodies; Abs to Growth Factors, Cytokines
 Applications Tested/Suitable for anti-CSF1R antibody   

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-CSF1R antibody    Suitable for use in Western Blot, Immunocytochemistry and ELISA.
Dilution: Western Blot: 0.1-0.2ug/ml Detects mouse M-CSFR at ~5ng/lane under non-reducing and reducing conditions.
Immunocytochemistry: 5-15ug/ml
ELISA (Direct): 0.5-1ug/ml. The detection limit is ~0.5ng/well.
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NCBI/Uniprot data below describe general gene information for CSF1R. It may not necessarily be applicable to this product.
 NCBI GI #    1916754
 NCBI GeneID    1436
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 UniProt Primary Accession #    P07333 [Other Products]
 UniProt Secondary Accession #    Q6LDW5; Q6LDY4; D3DQG2 [Other Products]
 UniProt Related Accession #    P07333; Q59HE0; Q6LEI2; Q86VW7 [Other Products]
 Molecular Weight    107,984 Da [Similar Products]
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 NCBI Official Full Name    macrophage colony stimulating factor receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
FMS; CSFR; FIM2; C-FMS; CD115
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor; CSF-1-R; CD115 antigen; FMS proto-oncogene; OTTHUMP00000160525; OTTHUMP00000224093; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-Fms
 Protein Family    Macrophage colony-stimulating factor 1 receptor
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS [Similar Products]
 UniProt Entry Name    CSF1R_HUMAN
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 NCBI Summary for CSF1R    The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq]
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 UniProt Comments for CSF1R    CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Protein kinase, TK; Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding

Biological Process: regulation of bone resorption; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; macrophage differentiation; monocyte differentiation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; protein amino acid autophosphorylation; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; positive regulation of protein amino acid phosphorylation; phosphatidylinositol metabolic process; inflammatory response; intercellular junction maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
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 Research Articles on CSF1R    1. data reveal quantitative site-specific changes in tyrosine phosphorylation induced by CSF-1R activation in epithelial cells and identify many candidate SRC-dependent substrates phosphorylated downstream of an RTK
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Macrophage Colony Stimulating Factor Receptor (M-CSFR, CSF-1)
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 MBS614988  Macrophage Colony Stimulating Factor Receptor (M-CSFR, CSF-1)  MBS626298  Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha (Granulocyte-macrophage Colony-stim...
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 MBS611456  Macrophage Colony Stimulating Factor Receptor, phosphorylated (Tyr723) (M-CSFR, CSF-1)
Products associated with anti-CSF1R antibodyPathways associated with anti-CSF1R antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >50 publications with CSF1R and GRB2
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-CSF1R antibodyOrgans/Tissues associated with anti-CSF1R antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1243 publications with CSF1R and Neoplasms
 Leukemia Antibodies  >808 publications with CSF1R and Leukemia
 Inflammation Antibodies  >522 publications with CSF1R and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >363 publications with CSF1R and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >237 publications with CSF1R and Lung Diseases
 Carcinoma Antibodies  >223 publications with CSF1R and Carcinoma
 Asthma Antibodies  >145 publications with CSF1R and Asthma
 Autoimmune Diseases Antibodies  >143 publications with CSF1R and Autoimmune Diseases
 Vascular Diseases Antibodies  >141 publications with CSF1R and Vascular Diseases
 Urogenital Neoplasms Antibodies  >140 publications with CSF1R and Urogenital Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2760 publications with CSF1R and Blood
 Bone Antibodies  >1644 publications with CSF1R and Bone
 Bone Marrow Antibodies  >1244 publications with CSF1R and Bone Marrow
 Lung Antibodies  >332 publications with CSF1R and Lung
 Spleen Antibodies  >231 publications with CSF1R and Spleen
 Liver Antibodies  >170 publications with CSF1R and Liver
 Brain Antibodies  >168 publications with CSF1R and Brain
 Muscle Antibodies  >114 publications with CSF1R and Muscle
 Embryonic Tissue Antibodies  >113 publications with CSF1R and Embryonic Tissue
 Kidney Antibodies  >108 publications with CSF1R and Kidney
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