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anti-CMA1 antibody :: Rabbit Mast Cell Chymase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714525 anti-CMA1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mast Cell Chymase (CMA1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Mast Cell Chymase polyclonal Antibody

 Product Synonym Names    chymase 1; mast cell; CMA1; CYH; MCT1; MGC119890; MGC119891; chymase
 Product Gene Name   

anti-CMA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    118938
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CMA1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CMA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CMA1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CMA1. It may not necessarily be applicable to this product.
 NCBI GI #    180542
 NCBI GeneID    1215
 NCBI Accession #    AAA52020.1 [Other Products]
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 UniProt Secondary Accession #    Q16018; Q3SY36; Q3SY37; Q9UDH5; B5BUM8 [Other Products]
 UniProt Related Accession #    P23946 [Other Products]
 Molecular Weight    14,893 Da [Similar Products]
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 NCBI Official Full Name    mast cell chymase
 NCBI Official Synonym Full Names    chymase 1, mast cell
 NCBI Official Symbol    CMA1 [Similar Products]
 NCBI Official Synonym Symbols   
CYH; MCT1; chymase
[Similar Products]
 NCBI Protein Information    chymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I
 UniProt Protein Name    Chymase
 UniProt Synonym Protein Names   
Alpha-chymase; Mast cell protease I
 Protein Family    Chymase
 UniProt Gene Name    CMA1 [Similar Products]
 UniProt Synonym Gene Names    CYH; CYM [Similar Products]
 UniProt Entry Name    CMA1_HUMAN
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 NCBI Summary for CMA1    This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CMA1    CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.39

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; peptide binding

Biological Process: extracellular matrix disassembly; interleukin-1 beta biosynthetic process; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; regulation of inflammatory response; midbrain development; protein processing; angiotensin maturation; proteolysis
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 Research Articles on CMA1    1. CMA1 gene single nucleotide polymorphisms is associated with essential hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CMA1 antibodyPathways associated with anti-CMA1 antibody
 Reference Product  PubMed Publications
 AGT antibody  >6 publications with CMA1 and AGT
 REN antibody  >2 publications with CMA1 and REN
 ACE2 antibody  >1 publications with CMA1 and ACE2
 KITLG antibody  >1 publications with CMA1 and KITLG
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-CMA1 antibodyOrgans/Tissues associated with anti-CMA1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with CMA1 and Inflammation
 Lung Diseases Antibodies  >10 publications with CMA1 and Lung Diseases
 Fibrosis Antibodies  >9 publications with CMA1 and Fibrosis
 Heart Diseases Antibodies  >8 publications with CMA1 and Heart Diseases
 Hypertension Antibodies  >8 publications with CMA1 and Hypertension
 Hypertrophy Antibodies  >5 publications with CMA1 and Hypertrophy
 Necrosis Antibodies  >4 publications with CMA1 and Necrosis
 Pulmonary Fibrosis Antibodies  >2 publications with CMA1 and Pulmonary Fibrosis
 Hypertrophy, Left Ventricular Antibodies  >2 publications with CMA1 and Hypertrophy, Left Ventricular
 Uterine Cervical Neoplasms Antibodies  >1 publications with CMA1 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with CMA1 and Mixed
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