NP_002414.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
matrilysin preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 7 (matrilysin, uterine)
NCBI Protein Information
matrilysin; matrin; pump-1 protease; OTTHUMP00000045867; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine)
UniProt Protein Name
Matrilysin
UniProt Synonym Protein Names
Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase
UniProt Synonym Gene Names
UniProt Entry Name
MMP7_HUMAN
NCBI Summary for MMP7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
UniProt Comments for MMP7
MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family.
Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.23
Chromosomal Location of Human Ortholog: 11q22.2
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity
Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; defense response to Gram-positive bacterium; antibacterial peptide biosynthetic process; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation
Research Articles on MMP7
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Products associated with anti-MMP7 antibody
Pathways associated with anti-MMP7 antibody
Diseases associated with anti-MMP7 antibody
Organs/Tissues associated with anti-MMP7 antibody
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