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anti-MC4R antibody :: Rabbit Melanocortin receptor 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS524440
Western Blot
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melanocortin receptor 4 (MC4R), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Mouse Melanocortin receptor 4, Affinity Purified, (Polyclonal), (Rabbit IgG)

 Product Gene Name   

anti-MC4R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    155541
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat, Human
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 Specificity    This antibody is specific for mouse, rat, and human MC4R.
 Form/Format    Affinity Purified
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 Presentation    100 ug (MBS524440) or 20 ug (MBS524440-S) purified IgG buffered in PBS and 0.02% NaN3 (Purified from serum via Affinity Chromatography). For maximum recovery of contents, spin down tube before use.
 Immunogen    15 amino acid synthetic peptide located within the 1st extracellular domain of mouse MC4R.
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 Preparation and Storage    Store at + 4C. For long term storage, aliquot and freeze unused portion at -20C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MC4R antibody

   Melanocortin 4 receptor is a G-protein-coupled receptor from the melanocortin receptor family that binds amelanocyte stimulating hormon ~(a-MSH). These receptors transduce signals provided by a-MSH by coupling to the G-protein and activating adenyl ate cyclase). MC4R is located mainly in the hypothalamus in the brain and it is responsible for appetite and satiety regulation. It also plays a role in energy homeostasis and somatic growth. Mutations in MC4R have been associated with inherited obesity2.
 Applications Tested/Suitable for anti-MC4R antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)-Paraffin

 Application Notes for anti-MC4R antibody    This antibody is suitable for use in ELISA, Western Blot (2 ug/mL) and Immunohistochemistry with FFPE sections (10 ug/mL). This antibody has not been tested in other applications.
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 Western Blot of anti-MC4R antibody    (2ug/ml) staining of Human Cerebellum (A) and Rat Brain (B) lysates (35 ug protein in RIPA buffer).
Primary incubation was 1 hour. Detected by chemiluminescence.
anti-MC4R antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.
 NCBI GI #    119508433
 NCBI GeneID    4160
 NCBI Accession #    NP_005903.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005912.2 [Other Products]
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 UniProt Secondary Accession #    Q16317; Q3MIJ6; B2RAC3 [Other Products]
 UniProt Related Accession #    P32245 [Other Products]
 Molecular Weight    36,943 Da
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 NCBI Official Full Name    melanocortin receptor 4
 NCBI Official Synonym Full Names    melanocortin 4 receptor
 NCBI Official Symbol    MC4R [Similar Products]
 NCBI Protein Information    melanocortin receptor 4
 UniProt Protein Name    Melanocortin receptor 4
 Protein Family    Melanocortin receptor
 UniProt Gene Name    MC4R [Similar Products]
 UniProt Synonym Gene Names    MC4-R [Similar Products]
 UniProt Entry Name    MC4R_HUMAN
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 NCBI Summary for MC4R    The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
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 UniProt Comments for MC4R    MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; nucleus; plasma membrane

Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; ubiquitin protein ligase binding

Biological Process: diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G-protein signaling, coupled to cAMP nucleotide second messenger; insulin secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; response to insulin stimulus

Disease: Obesity
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 Research Articles on MC4R    1. The interaction between FTO and MC4R polymorphisms is associated with the development of PCOS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MC4R antibodyPathways associated with anti-MC4R antibody
 Reference Product  PubMed Publications
 POMC antibody  >387 publications with MC4R and POMC
 AGRP antibody  >145 publications with MC4R and AGRP
 MC1R antibody  >81 publications with MC4R and MC1R
 LEP antibody  >29 publications with MC4R and LEP
 CRH antibody  >16 publications with MC4R and CRH
 GIPR antibody  >7 publications with MC4R and GIPR
 GLP1R antibody  >5 publications with MC4R and GLP1R
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-MC4R antibodyOrgans/Tissues associated with anti-MC4R antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >703 publications with MC4R and Obesity
 Body Weight Antibodies  >651 publications with MC4R and Body Weight
 Weight Gain Antibodies  >101 publications with MC4R and Weight Gain
 Weight Loss Antibodies  >96 publications with MC4R and Weight Loss
 Hyperphagia Antibodies  >77 publications with MC4R and Hyperphagia
 Insulin Resistance Antibodies  >62 publications with MC4R and Insulin Resistance
 Hyperinsulinism Antibodies  >50 publications with MC4R and Hyperinsulinism
 Cardiovascular Diseases Antibodies  >47 publications with MC4R and Cardiovascular Diseases
 Hypertension Antibodies  >46 publications with MC4R and Hypertension
 Inflammation Antibodies  >39 publications with MC4R and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >345 publications with MC4R and Brain
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