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anti-MTNR1A antibody :: Rabbit Melatonin Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551064
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 Product Name   

Melatonin Receptor (MTNR1A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti Melatonin Receptor Polyclonal

 Product Synonym Names    Rabbit anti Melatonin receptor Polyclonal purified; mel1a; mtnr-1a; mtnr1a; melatonin; polyclonal
 Product Gene Name   

anti-MTNR1A antibody

[Similar Products]
 Product Synonym Gene Name    Melatonin [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600665
 3D Structure    ModBase 3D Structure for P48039
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Serum IgG fraction was purified by Protein G affinity chromatography.
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal Melatonin Receptor antibody was produced from sera of mice immunized with synthetic protein containing MTNR1A antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
 Other Notes    Small volumes of anti-MTNR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MTNR1A antibody    Polyclonal
 Applications Tested/Suitable for anti-MTNR1A antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-MTNR1A antibody    ELISA: A suitable range of concentrations of this antibody for IHC is 1-2 ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemistry of FFPE Rat brain sections expressing MNTR-1A.
It was used as primary antibody, dilution 1:1000.
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 Immunohistochemistry of anti-MTNR1A antibody    anti-MTNR1A antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for MTNR1A. It may not necessarily be applicable to this product.
 NCBI GI #    5174593
 NCBI GeneID    4543
 NCBI Accession #    NP_005949.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005958.3 [Other Products]
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 UniProt Primary Accession #    P48039 [Other Products]
 UniProt Secondary Accession #    A0AVC5; B0M0L2 [Other Products]
 UniProt Related Accession #    P48039; Q29RX9; Q8WZ72 [Other Products]
 Molecular Weight    39,375 Da
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 NCBI Official Full Name    melatonin receptor type 1A
 UniProt Protein Name    Melatonin receptor type 1A
 Protein Family    Melatonin receptor
 UniProt Gene Name    MTNR1A [Similar Products]
 UniProt Synonym Gene Names    Mel-1A-R [Similar Products]
 UniProt Entry Name    MTR1A_HUMAN
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 NCBI Summary for MTNR1A    This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MTNR1A    MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; hormone binding; melatonin receptor activity

Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior
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Product References and Citations for anti-MTNR1A antibody

   removal of Melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse .Invest. Ophthalmol. Vis. Sci., Apr 2010; 51: 1628.
common genetic variation near Melatonin receptor mtnr1b contributes to raised plasma glucose and increased risk of type 2 diabetes among indian asians and european caucasians .Diabetes, Nov 2009; 58: 2703 - 2708.
the expression of mt1 Melatonin receptor and ki-67 antigen in melanoma malignum .Anticancer Res, Oct 2009; 29: 3887 - 3895.
melatonin modulates visual function and cell viability in the mouse retina via the mt1 Melatonin receptor .PNAS, Sep 2009; 106: 15043 - 15048.
association between Melatonin receptor 1a gene polymorphism and reproductive performance in dorset ewes .J Anim Sci, Aug 2009; 87: 2485 - 2488.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MTNR1A antibodyPathways associated with anti-MTNR1A antibody
 Reference Product  PubMed Publications
 MTNR1B antibody  >16 publications with MTNR1A and MTNR1B
 GPR50 antibody  >3 publications with MTNR1A and GPR50
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Small Ligand GPCRs Pathway antibodies  Small Ligand GPCRs Pathway Diagram
Diseases associated with anti-MTNR1A antibodyOrgans/Tissues associated with anti-MTNR1A antibody
 Disease Name  Pubmed Publications
 Child Development Disorders, Pervasive Antibodies  >2 publications with MTNR1A and Child Development Disorders, Pervasive
 Neoplasms Antibodies  >1 publications with MTNR1A and Neoplasms
 Arthritis, Rheumatoid Antibodies  >1 publications with MTNR1A and Arthritis, Rheumatoid
 Hyperglycemia Antibodies  >1 publications with MTNR1A and Hyperglycemia
 Diabetes Mellitus Antibodies  >1 publications with MTNR1A and Diabetes Mellitus
 Central Nervous System Diseases Antibodies  >1 publications with MTNR1A and Central Nervous System Diseases
 Insulin Resistance Antibodies  >1 publications with MTNR1A and Insulin Resistance
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with MTNR1A and Liver
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