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anti-MEN1 antibody :: Rabbit Menin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS840892 anti-MEN1 antibody
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Menin (MEN1), Polyclonal Antibody

 Also Known As   

Menin Antibody

 Product Synonym Names    MEAI; Multiple Endocrine Adenomatosis 1; ZES; Zollinger-Ellison Syndrome; SCG2; Suppressor Candidate Gene 2
 Product Gene Name   

anti-MEN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131100
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purified
 Form/Format    100 ul affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Appearance: Colorless liquid
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 Immunogen    Synthetic peptide of human Menin
 Handling    The antibody solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of anti-MEN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MEN1 antibody

   Background: Menin (multiple endocrine neoplasia I, MEN1, MEAI, SCG2) is a nuclear tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1). Menin can activate the transcription of differentiation-regulating genes by covalent histone modification. In osteoblasts, the interaction of menin and the TGFbeta/Smad3 pathway negatively regulates BMP2/Smad1/5- and Runx2-dependent transcription activities leading to inhibition of late-stage differentiation. Menin regulates the expression of IGFBP-2 by influencing the IGFBP-2 promoter. Ectopic overexpression of menin via adenoviruses induces apoptosis in murine embryonic fibroblasts in a Bax/Bak-dependent manner. Two mRNA exist and two variants of the shorter mRNA have alternative splicing that changes the CDS. Five variants where alternative splicing takes place in the 5' UTR have been identified.
 Applications Tested/Suitable for anti-MEN1 antibody   

Western Blot (WB)

 Application Notes for anti-MEN1 antibody    Western blotting (1:500 - 1:2000). However, the optimal concentrations should be determined individually. 293T cell lysate can be used as a positive control. The antibody recognizes the Menin of human, mouse, and rat origins. Reactivity to other species has not been tested.
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NCBI/Uniprot data below describe general gene information for MEN1. It may not necessarily be applicable to this product.
 NCBI GI #    18860839
 NCBI GeneID    4221
 NCBI Accession #    NP_000235.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000244.3 [Other Products]
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 UniProt Secondary Accession #    O00632; Q9BUF0; Q9BUK2; A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2 [Other Products]
 UniProt Related Accession #    O00255 [Other Products]
 Molecular Weight    63,748 Da [Similar Products]
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 NCBI Official Full Name    menin isoform 1
 NCBI Official Synonym Full Names    multiple endocrine neoplasia I
 NCBI Official Symbol    MEN1 [Similar Products]
 NCBI Official Synonym Symbols   
MEAI; SCG2
[Similar Products]
 NCBI Protein Information    menin
 UniProt Protein Name    Menin
 Protein Family    Menin
 UniProt Gene Name    MEN1 [Similar Products]
 UniProt Synonym Gene Names    SCG2 [Similar Products]
 UniProt Entry Name    MEN1_HUMAN
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 NCBI Summary for MEN1    This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
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 UniProt Comments for MEN1    MEN1: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; histone methyltransferase complex; nuclear matrix; protein complex; cytoplasm; chromatin; nucleus; cytosol; cleavage furrow

Molecular Function: protein binding, bridging; Y-form DNA binding; protein binding; four-way junction DNA binding; sequence-specific DNA binding; double-stranded DNA binding; protein N-terminus binding; chromatin binding; histone-lysine N-methyltransferase activity

Biological Process: negative regulation of JNK cascade; maternal process involved in pregnancy; positive regulation of protein binding; positive regulation of caspase activity; palate development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; response to gamma radiation; hemopoiesis; negative regulation of osteoblast differentiation; cell cycle arrest; response to UV; leukocyte homeostasis; transcription initiation from RNA polymerase II promoter; positive regulation of histone methylation; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of cyclin-dependent protein kinase activity; positive regulation of transforming growth factor beta receptor signaling pathway; MAPKKK cascade; negative regulation of organ growth; DNA repair; regulation of activin receptor signaling pathway; osteoblast development; embryonic skeletal morphogenesis; chromatin remodeling; negative regulation of telomerase activity; positive regulation of osteoblast differentiation; positive regulation of cell division; gene expression; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; osteoblast fate commitment

Disease: Multiple Endocrine Neoplasia, Type I
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 Research Articles on MEN1    1. Menin expression is higher in castration-resistant prostate cancer than in both hormone-naive prostate cancer and benign prostate tissue, and high menin expression correlates with poor overall survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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