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anti-NF2 antibody :: Rabbit anti-Human Merlin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628870 anti-NF2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Merlin (NF2), Polyclonal Antibody

 Also Known As   

Merlin, NT (Moesin-ezrin-radixin-like Protein, ACN, BANF, Neurofibromin 2, Neurofibromin-2, NF2, Schwannomerlin, Schwannomin, SCH)

 Product Synonym Names    Anti -Merlin, NT (Moesin-ezrin-radixin-like Protein, ACN, BANF, Neurofibromin 2, Neurofibromin-2, NF2, Schwannomerlin, Schwannomin, SCH)
 Product Gene Name   

anti-NF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 22; NC_000022.10 (29999545..30094589). Location: 22q12.2
 OMIM    101000
 3D Structure    ModBase 3D Structure for P35240
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human Merlin.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, 0.25% sodium azide.
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 Immunogen    Synthetic peptide selected from the N-terminal region of human Merlin (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-NF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NF2 antibody

   Merlin is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport.
 Product Categories/Family for anti-NF2 antibody    Antibodies; Abs to Tumor Suppressors
 Applications Tested/Suitable for anti-NF2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-NF2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for NF2. It may not necessarily be applicable to this product.
 NCBI GI #    32967514
 NCBI GeneID    4771
 NCBI Accession #    NP_861969.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_181831.2 [Other Products]
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 UniProt Primary Accession #    P35240 [Other Products]
 UniProt Secondary Accession #    O95683; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3 [Other Products]
 UniProt Related Accession #    P35240 [Other Products]
 Molecular Weight    69,690 Da [Similar Products]
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 NCBI Official Full Name    merlin isoform 7
 NCBI Official Synonym Full Names    neurofibromin 2 (merlin)
 NCBI Official Symbol    NF2 [Similar Products]
 NCBI Official Synonym Symbols   
ACN; SCH; BANF
[Similar Products]
 NCBI Protein Information    merlin; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma)
 UniProt Protein Name    Merlin
 UniProt Synonym Protein Names   
Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
 Protein Family    Merlin
 UniProt Gene Name    NF2 [Similar Products]
 UniProt Synonym Gene Names    SCH [Similar Products]
 UniProt Entry Name    MERL_HUMAN
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 NCBI Summary for NF2    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NF2    Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Tumor suppressor

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; extrinsic to membrane; adherens junction; cytoskeleton; membrane; perinuclear region of cytoplasm; apical part of cell; lamellipodium; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow

Molecular Function: protein binding; actin binding

Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; Schwann cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; positive regulation of cell differentiation; negative regulation of cell migration; negative regulation of JAK-STAT cascade

Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
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 Research Articles on NF2    1. Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NF2 antibodyDiseases associated with anti-NF2 antibody
 Products by Pathway  Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1008 publications with NF2 and Neoplasms
 Nervous System Diseases Antibodies  >889 publications with NF2 and Nervous System Diseases
 Neurofibromatosis 2 Antibodies  >789 publications with NF2 and Neurofibromatosis 2
 Meningioma Antibodies  >253 publications with NF2 and Meningioma
 Schwannomatosis Antibodies  >77 publications with NF2 and Schwannomatosis
 Mesothelioma Antibodies  >57 publications with NF2 and Mesothelioma
 Meningioma, familial Antibodies  >55 publications with NF2 and Meningioma, familial
 Eye Diseases Antibodies  >50 publications with NF2 and Eye Diseases
 Skin Neoplasms Antibodies  >45 publications with NF2 and Skin Neoplasms
 Carcinoma Antibodies  >39 publications with NF2 and Carcinoma
Organs/Tissues associated with anti-NF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >280 publications with NF2 and Brain
 Skin Antibodies  >64 publications with NF2 and Skin
 Eye Antibodies  >45 publications with NF2 and Eye
 Bone Antibodies  >35 publications with NF2 and Bone
 Lung Antibodies  >32 publications with NF2 and Lung
 Muscle Antibodies  >29 publications with NF2 and Muscle
 Vascular Antibodies  >27 publications with NF2 and Vascular
 Liver Antibodies  >17 publications with NF2 and Liver
 Kidney Antibodies  >15 publications with NF2 and Kidney
 Prostate Antibodies  >11 publications with NF2 and Prostate
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