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anti-Slc19a1 antibody :: Sheep Methotrexate Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS340544 anti-Slc19a1 antibody
Unit / Price
0.1 mL  /  $920 +1 FREE 8GB USB
1 mL  /  $4,780 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Methotrexate (Slc19a1), Polyclonal Antibody

 Also Known As   

Methotrexate

 Product Synonym Names    MTX; amethopterin
 Product Gene Name   

anti-Slc19a1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q62866
 Clonality    Polyclonal
 Host    Sheep
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 Form/Format    Ig Fraction - Liquid
 Concentration    >5mg/ml (U.V.abs @ 280nm) (lot specific)
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 Immunogen    Methotrexate-BSA
 Buffer    20mM Phosphate, 150mM Sodium Chloride
 Preservative    0.09% Sodium Azide
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 Preparation and Storage    Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.
 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of anti-Slc19a1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Slc19a1 antibody

   Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.
 Product Categories/Family for anti-Slc19a1 antibody    Polyclonal Antibodies; Drugs of Abuse; Therapeutic Drugs; Methotrexate
 Applications Tested/Suitable for anti-Slc19a1 antibody   

ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays

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NCBI/Uniprot data below describe general gene information for Slc19a1. It may not necessarily be applicable to this product.
 NCBI GI #    5733102
 NCBI GeneID    29723
 NCBI Accession #    AAD49426.1 [Other Products]
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 UniProt Primary Accession #    Q62866 [Other Products]
 UniProt Related Accession #    Q62866 [Other Products]
 Molecular Weight    58,094 Da [Similar Products]
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 NCBI Official Full Name    methotrexate carrier
 NCBI Official Synonym Full Names    solute carrier family 19 member 1
 NCBI Official Symbol    Slc19a1 [Similar Products]
 NCBI Official Synonym Symbols   
MTX1
[Similar Products]
 NCBI Protein Information    folate transporter 1
 UniProt Protein Name    Folate transporter 1
 UniProt Synonym Protein Names   
Reduced folate carrier 1; RFC-1; RFC1; Solute carrier family 19 member 1
 UniProt Gene Name    Slc19a1 [Similar Products]
 UniProt Synonym Gene Names    RFC-1; RFC1 [Similar Products]
 UniProt Entry Name    S19A1_RAT
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 NCBI Summary for Slc19a1    mouse homolog facilitates transport of methotrexate and folic acid [RGD, Feb 2006]
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 UniProt Comments for Slc19a1    Transporter for the intake of folate, reduced folates and methotrexate.
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 Research Articles on Slc19a1    1. decreased levels of PCFT and RFC expression in rat PPM are due to decreased association of these proteins with lipid rafts (LR) at the PPM
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Slc19a1 antibodyPathways associated with anti-Slc19a1 antibody
 Reference Product  PubMed Publications
 Mtrr antibody  >32 publications with Slc19a1 and Mtrr
 Slc46a1 antibody  >25 publications with Slc19a1 and Slc46a1
 Fpgs antibody  >23 publications with Slc19a1 and Fpgs
 Mthfd1 antibody  >19 publications with Slc19a1 and Mthfd1
 Tp53 antibody  >2 publications with Slc19a1 and Tp53
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Folate And Pterines Pathway antibodies  Metabolism Of Folate And Pterines Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
Organs/Tissues associated with anti-Slc19a1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >43 publications with Slc19a1 and Kidney
 Brain Antibodies  >30 publications with Slc19a1 and Brain
 Heart Antibodies  >18 publications with Slc19a1 and Heart
 Embryonic Tissue Antibodies  >15 publications with Slc19a1 and Embryonic Tissue
 Eye Antibodies  >10 publications with Slc19a1 and Eye
 Spleen Antibodies  >10 publications with Slc19a1 and Spleen
 Pancreas Antibodies  >5 publications with Slc19a1 and Pancreas
 Thymus Antibodies  >2 publications with Slc19a1 and Thymus
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