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anti-MGMT antibody :: Rabbit anti-Human Methylated-DNA--protein-cysteine methyltransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7003994
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Methylated-DNA--protein-cysteine methyltransferase (MGMT), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Methylated-DNA--protein-cysteine methyltransferase polyclonal Antibody

 Product Synonym Names    MGMT
 Product Gene Name   

anti-MGMT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    156569
 3D Structure    ModBase 3D Structure for P16455
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Methylated-DNA--protein-cysteine methyltransferase
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8825 / sc-8824 / sc-8826 / sc-28241
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MGMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MGMT antibody

   Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
 Product Categories/Family for anti-MGMT antibody    Epigenetics and Nuclear Signaling
 Applications Tested/Suitable for anti-MGMT antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-MGMT antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-MGMT antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS7003994 at dilution of 1:20
anti-MGMT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MGMT antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7003994 at dilution of 1:20
anti-MGMT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MGMT. It may not necessarily be applicable to this product.
 NCBI GI #    530394832
 NCBI GeneID    4255
 NCBI Accession #    XP_005252739.1 [Other Products]
 NCBI GenBank Nucleotide #    XP_005252739.1 [Other Products]
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 UniProt Primary Accession #    P16455 [Other Products]
 UniProt Secondary Accession #    Q5VY78 [Other Products]
 UniProt Related Accession #    P16455 [Other Products]
 Molecular Weight    21,646 Da [Similar Products]
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 NCBI Official Full Name    methylated-DNA--protein-cysteine methyltransferase isoform X2
 NCBI Official Synonym Full Names    O-6-methylguanine-DNA methyltransferase
 NCBI Official Symbol    MGMT [Similar Products]
 NCBI Protein Information    methylated-DNA--protein-cysteine methyltransferase
 UniProt Protein Name    Methylated-DNA--protein-cysteine methyltransferase
 UniProt Synonym Protein Names   
6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
 Protein Family    Methylated-DNA--protein-cysteine methyltransferase
 UniProt Gene Name    MGMT [Similar Products]
 UniProt Synonym Gene Names    MGMT [Similar Products]
 UniProt Entry Name    MGMT_HUMAN
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 NCBI Summary for MGMT    Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
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 UniProt Comments for MGMT    MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.

Protein type: Apoptosis; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator; DNA repair, damage

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: membrane; nucleoplasm; nucleus

Molecular Function: calcium ion binding; damaged DNA binding; DNA binding; DNA-methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity

Biological Process: DNA dealkylation; DNA ligation; DNA methylation; DNA repair; positive regulation of DNA repair; regulation of caspase activity; response to drug; response to ethanol; response to folic acid; response to toxin
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 Research Articles on MGMT    1. Report MGMT promoter CpG island methylation in glioblastoma using pyrosequencing.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MGMT antibodyDiseases associated with anti-MGMT antibody
 Reference Product  PubMed Publications
 MLH1 antibody  >239 publications with MGMT and MLH1
 TP53 antibody  >128 publications with MGMT and TP53
 KRAS antibody  >88 publications with MGMT and KRAS
 HIF1A antibody  >5 publications with MGMT and HIF1A
 NRAS antibody  >4 publications with MGMT and NRAS
 UBC antibody  >2 publications with MGMT and UBC
 MYB antibody  >1 publications with MGMT and MYB
 HRAS antibody  >1 publications with MGMT and HRAS
 Disease Name  Pubmed Publications
 Glioma Antibodies  >1103 publications with MGMT and Glioma
 Nervous System Diseases Antibodies  >951 publications with MGMT and Nervous System Diseases
 Brain Neoplasms Antibodies  >925 publications with MGMT and Brain Neoplasms
 Glioblastoma Antibodies  >858 publications with MGMT and Glioblastoma
 Carcinoma Antibodies  >482 publications with MGMT and Carcinoma
 Recurrence Antibodies  >243 publications with MGMT and Recurrence
 Adenocarcinoma Antibodies  >181 publications with MGMT and Adenocarcinoma
 Lung Neoplasms Antibodies  >151 publications with MGMT and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >149 publications with MGMT and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >127 publications with MGMT and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-MGMT antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1030 publications with MGMT and Brain
 Blood Antibodies  >272 publications with MGMT and Blood
 Lung Antibodies  >201 publications with MGMT and Lung
 Liver Antibodies  >128 publications with MGMT and Liver
 Bone Antibodies  >114 publications with MGMT and Bone
 Stomach Antibodies  >74 publications with MGMT and Stomach
 Vascular Antibodies  >57 publications with MGMT and Vascular
 Intestine Antibodies  >56 publications with MGMT and Intestine
 Lymph Antibodies  >55 publications with MGMT and Lymph
 Skin Antibodies  >52 publications with MGMT and Skin
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