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anti-MAP1LC3A antibody :: Rabbit anti-Human Microtubule-associated proteins 1A/1B light chain 3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002940
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Microtubule-associated proteins 1A/1B light chain 3A polyclonal Antibody(MAP1LC3A)

 Product Synonym Names    Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha; MAP1LC3A
 Product Gene Name   

anti-MAP1LC3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601242
 3D Structure    ModBase 3D Structure for Q9H492
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Microtubule-associated proteins 1A/1B light chain 3A protein (1-120AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-134226 / sc-292354
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAP1LC3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAP1LC3A antibody

   Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
 Applications Tested/Suitable for anti-MAP1LC3A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-MAP1LC3A antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-MAP1LC3A antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7002940 at dilution of 1:100
anti-MAP1LC3A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAP1LC3A antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7002940 at dilution of 1:100
anti-MAP1LC3A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MAP1LC3A. It may not necessarily be applicable to this product.
 NCBI GI #    14210522
 NCBI GeneID    84557
 NCBI Accession #    NP_115903.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032514.3 [Other Products]
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 UniProt Primary Accession #    Q9H492 [Other Products]
 UniProt Secondary Accession #    Q9BXW5; E1P5P4; E1P5P5 [Other Products]
 UniProt Related Accession #    Q9H492 [Other Products]
 Molecular Weight    14,493 Da [Similar Products]
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 NCBI Official Full Name    microtubule-associated proteins 1A/1B light chain 3A isoform a
 NCBI Official Synonym Full Names    microtubule associated protein 1 light chain 3 alpha
 NCBI Official Symbol    MAP1LC3A [Similar Products]
 NCBI Official Synonym Symbols   
LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3
[Similar Products]
 NCBI Protein Information    microtubule-associated proteins 1A/1B light chain 3A
 UniProt Protein Name    Microtubule-associated proteins 1A/1B light chain 3A
 UniProt Synonym Protein Names   
Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAP1LC3A [Similar Products]
 UniProt Synonym Gene Names    MAP1A/MAP1B LC3 A [Similar Products]
 UniProt Entry Name    MLP3A_HUMAN
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 NCBI Summary for MAP1LC3A    MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
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 UniProt Comments for MAP1LC3A    LC3A: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Microtubule-binding; Autophagy; Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; microtubule

Molecular Function: microtubule binding; phosphatidylethanolamine binding; phospholipid binding; protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy; macromitophagy; mitochondrion degradation
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 Research Articles on MAP1LC3A    1. These results demonstrate the essential role of BECN1 in the functional formation of autophagosomes, but not in LC3B lipidation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP1LC3A antibodyPathways associated with anti-MAP1LC3A antibody
 Reference Product  PubMed Publications
 SQSTM1 antibody  >26 publications with MAP1LC3A and SQSTM1
 ATG5 antibody  >24 publications with MAP1LC3A and ATG5
 ATG7 antibody  >18 publications with MAP1LC3A and ATG7
 ULK1 antibody  >10 publications with MAP1LC3A and ULK1
 ATG4B antibody  >6 publications with MAP1LC3A and ATG4B
 ATG3 antibody  >3 publications with MAP1LC3A and ATG3
 ATG4A antibody  >2 publications with MAP1LC3A and ATG4A
 ATG13 antibody  >1 publications with MAP1LC3A and ATG13
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Mitophagy Pathway antibodies  Mitophagy Pathway Diagram
 Pink/Parkin Mediated Mitophagy Pathway antibodies  Pink/Parkin Mediated Mitophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-MAP1LC3A antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >16 publications with MAP1LC3A and Lung Neoplasms
 Nervous System Diseases Antibodies  >16 publications with MAP1LC3A and Nervous System Diseases
 Lung Diseases Antibodies  >15 publications with MAP1LC3A and Lung Diseases
 Breast Neoplasms Antibodies  >12 publications with MAP1LC3A and Breast Neoplasms
 Liver Neoplasms Antibodies  >7 publications with MAP1LC3A and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with MAP1LC3A and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >6 publications with MAP1LC3A and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with MAP1LC3A and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >5 publications with MAP1LC3A and Liver Diseases
 Cardiovascular Diseases Antibodies  >5 publications with MAP1LC3A and Cardiovascular Diseases
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