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anti-MFN2 antibody :: Rabbit Mitofusin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175286
Western Blot (WB)
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 Product Name   

Mitofusin 2 (MFN2), Polyclonal Antibody

 Also Known As   

Anti-Mitofusin 2 antibody

 Product Synonym Names    Mitofusin-2; mitofusin 2; CMT2A antibody; CMT2A2 antibody; CPRP 1 antibody; CPRP1 antibody; EC 3.6.5.- antibody; Fzo antibody; HSG antibody; hyperplasia suppressor gene antibody; Hypertension related protein 1 antibody; KIAA0214 antibody; MARF antibody; MFN 2 antibody; MFN2 antibody; MFN2_HUMAN antibody; Mitochondrial assembly regulatory factor antibody; Mitofusin-2 antibody; Mitofusin2 antibody; Transmembrane GTPase MFN2 antibody
 Product Gene Name   

anti-MFN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609260
 3D Structure    ModBase 3D Structure for O95140
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human Mitofusin 2 (6-24aa SRCNSIVTVKKNKRHMAEV), different from the related rat and mouse sequences by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MFN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MFN2 antibody

   Description: Rabbit IgG polyclonal antibody for Mitofusin-2(MFN2) detection. Tested with WB in Human, Mouse, Rat.
Background: Mitofusin 2(MFN2) is a mitochondrial transmembrane GTPase regulating mitochondrial fusion and that the nucleotide-dependent activation of MFN2 concomitantly protects the organelle from permeability transition. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. It is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. This protein contains an N-terminal GTPase domain and a transmembrane domain near the C terminus. It shares 60% identity with MFN1. When stably expressed in COS-7 cells, MFN2 colocalizes with mitochondrial markers. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.
 Applications Tested/Suitable for anti-MFN2 antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-MFN2 antibody    Anti-Mitofusin 2 antibody, MBS175286, Western blotting
All lanes: Anti Mitofusin 2 (MBS175286) at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: HELA Whole Cell Lysate at 40ug
Predicted bind size: 86KD
Observed bind size: 86KD
anti-MFN2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MFN2. It may not necessarily be applicable to this product.
 NCBI GI #    47605777
 NCBI GeneID    9927
 NCBI Accession #    O95140.3 [Other Products]
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 UniProt Primary Accession #    O95140 [Other Products]
 UniProt Secondary Accession #    O95572; Q5JXC3; Q5JXC4; Q9H131; Q9NSX8; A8K1B3 [Other Products]
 UniProt Related Accession #    O95140 [Other Products]
 Molecular Weight    50,041 Da
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 NCBI Official Full Name    Mitofusin-2
 NCBI Official Synonym Full Names    mitofusin 2
 NCBI Official Symbol    MFN2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    mitofusin-2; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor
 UniProt Protein Name    Mitofusin-2
 UniProt Synonym Protein Names   
Transmembrane GTPase MFN2
 Protein Family    Mitofusin
 UniProt Gene Name    MFN2 [Similar Products]
 UniProt Synonym Gene Names    CPRP1; KIAA0214 [Similar Products]
 UniProt Entry Name    MFN2_HUMAN
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 NCBI Summary for MFN2    This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MFN2    MFN2: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6); also referred to as autosomal dominant hereditary motor and sensory neuropathy VI (HMSN6). CMT6 is an autosomal dominant form of axonal CMT associated with optic atrophy. Belongs to the mitofusin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.5.-; Cytoskeletal; Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Cell cycle regulation; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; integral to membrane; cytosol; intrinsic to mitochondrial outer membrane

Molecular Function: GTPase activity; protein binding; GTP binding; ubiquitin protein ligase binding

Biological Process: mitochondrial fusion; negative regulation of smooth muscle cell proliferation; apoptosis; mitochondrial membrane organization and biogenesis; blastocyst formation; mitochondrion localization; response to unfolded protein; camera-type eye morphogenesis; autophagy; negative regulation of Ras protein signal transduction; blood coagulation; cell cycle arrest; protein targeting to mitochondrion

Disease: Charcot-marie-tooth Disease, Axonal, Type 2a2; Neuropathy, Hereditary Motor And Sensory, Type Vi
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 Research Articles on MFN2    1. atherosclerotic lesions of both mice and human compared with healthy counterparts. Here, we observed that Mfn2 increased cellular cholesterol transporter expression in macrophages by upregulating peroxisome proliferator-activated receptor-gamma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MFN2 antibodyPathways associated with anti-MFN2 antibody
 Reference Product  PubMed Publications
 OPA1 antibody  >100 publications with MFN2 and OPA1
 FIS1 antibody  >43 publications with MFN2 and FIS1
 DNM1L antibody  >37 publications with MFN2 and DNM1L
 GDAP1 antibody  >29 publications with MFN2 and GDAP1
 KIF1B antibody  >11 publications with MFN2 and KIF1B
 PARK2 antibody  >9 publications with MFN2 and PARK2
 BAK1 antibody  >3 publications with MFN2 and BAK1
 MARCH5 antibody  >3 publications with MFN2 and MARCH5
 IL6 antibody  >2 publications with MFN2 and IL6
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-MFN2 antibodyOrgans/Tissues associated with anti-MFN2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >38 publications with MFN2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >31 publications with MFN2 and Heart Diseases
 Muscular Diseases Antibodies  >17 publications with MFN2 and Muscular Diseases
 Carcinoma Antibodies  >15 publications with MFN2 and Carcinoma
 Nerve Degeneration Antibodies  >15 publications with MFN2 and Nerve Degeneration
 Liver Diseases Antibodies  >14 publications with MFN2 and Liver Diseases
 Hyperplasia Antibodies  >12 publications with MFN2 and Hyperplasia
 Necrosis Antibodies  >11 publications with MFN2 and Necrosis
 Heart Failure Antibodies  >11 publications with MFN2 and Heart Failure
 Cardiomyopathies Antibodies  >9 publications with MFN2 and Cardiomyopathies
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >139 publications with MFN2 and Muscle
 Nerve Antibodies  >70 publications with MFN2 and Nerve
 Heart Antibodies  >56 publications with MFN2 and Heart
 Brain Antibodies  >46 publications with MFN2 and Brain
 Liver Antibodies  >30 publications with MFN2 and Liver
 Blood Antibodies  >28 publications with MFN2 and Blood
 Vascular Antibodies  >20 publications with MFN2 and Vascular
 Kidney Antibodies  >14 publications with MFN2 and Kidney
 Embryonic Tissue Antibodies  >12 publications with MFN2 and Embryonic Tissue
 Lung Antibodies  >12 publications with MFN2 and Lung
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