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anti-MAOA antibody :: Goat Monoamine Oxidase A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421298
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Monoamine Oxidase A (MAOA), Polyclonal Antibody

 Also Known As   

Goat anti-Monoamine Oxidase A Antibody

 Product Synonym Names    MAOA; monoamine oxidase A; HGNC: 6833; RP1-201D17__B.2; monoamine oxidase A antibody; HGNC: 6833 antibody; MAOA antibody; RP1-201D17__B.2 antibody; Monoamine Oxidase A; Monoamine Oxidase A
 Product Gene Name   

anti-MAOA antibody

[Similar Products]
 Antibody/Peptide Pairs    Monoamine Oxidase A peptide (MBS426437) is used for blocking the activity of Monoamine Oxidase A antibody (MBS421298)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DAPWEAQHAD KWDK
 OMIM    300615
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DAPWEAQHADKWDK, from the internal region of the protein sequence according to NP_000231.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-MAOA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAOA antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MAOA antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 70kDa band observed in Human Heart lysates o(calculated MW of 60. 0kDa according to NP_000231.1). In transfected HEK293 transiently expressing MAOA a band of approx. 60 kDa is observed. This band is not observed in the non-transfected HEK293. The user is warned for non-specific background in Western blot. Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-MAOA antibody    (0.3ug/ml) staining of human heart lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
anti-MAOA antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-MAOA antibody    HEK293 overexpressing MAOA (RC207276) and probed (mock transfection in first lane), tested by Origene.
anti-MAOA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAOA. It may not necessarily be applicable to this product.
 NCBI GI #    4557735
 NCBI GeneID    4128
 NCBI Accession #    NP_000231.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000240.3 [Other Products]
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 UniProt Secondary Accession #    Q16426; B4DF46 [Other Products]
 UniProt Related Accession #    P21397 [Other Products]
 Molecular Weight    44,848 Da
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 NCBI Official Full Name    amine oxidase
 NCBI Official Synonym Full Names    monoamine oxidase A
 NCBI Official Symbol    MAOA [Similar Products]
 NCBI Official Synonym Symbols   
MAO-A
[Similar Products]
 NCBI Protein Information    amine oxidase [flavin-containing] A
 UniProt Protein Name    Amine oxidase [flavin-containing] A
 UniProt Synonym Protein Names   
Monoamine oxidase type A; MAO-A
 Protein Family    Amine oxidase
 UniProt Gene Name    MAOA [Similar Products]
 UniProt Synonym Gene Names    MAO-A [Similar Products]
 UniProt Entry Name    AOFA_HUMAN
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 NCBI Summary for MAOA    This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
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 UniProt Comments for MAOA    MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.

Protein type: EC 1.4.3.4; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - arginine and proline; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: amine oxidase activity; FAD binding; serotonin binding

Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; neurotransmitter metabolic process; phenylethylamine metabolic process; serotonin metabolic process

Disease: Brunner Syndrome
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 Research Articles on MAOA    1. The 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAOA antibodyPathways associated with anti-MAOA antibody
 Reference Product  PubMed Publications
 COMT antibody  >113 publications with MAOA and COMT
 DBH antibody  >28 publications with MAOA and DBH
 DDC antibody  >11 publications with MAOA and DDC
 PNMT antibody  >4 publications with MAOA and PNMT
 ADH1B antibody  >2 publications with MAOA and ADH1B
 CYP2D6 antibody  >1 publications with MAOA and CYP2D6
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amine Oxidase Reactions Pathway antibodies  Amine Oxidase Reactions Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway antibodies  Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
Diseases associated with anti-MAOA antibodyOrgans/Tissues associated with anti-MAOA antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >303 publications with MAOA and Mental Disorders
 Nervous System Diseases Antibodies  >95 publications with MAOA and Nervous System Diseases
 Antisocial Personality Disorder Antibodies  >58 publications with MAOA and Antisocial Personality Disorder
 Depressive Disorder Antibodies  >58 publications with MAOA and Depressive Disorder
 Brain Diseases Antibodies  >53 publications with MAOA and Brain Diseases
 Anxiety Disorders Antibodies  >39 publications with MAOA and Anxiety Disorders
 Autistic Disorder Antibodies  >12 publications with MAOA and Autistic Disorder
 Cardiovascular Diseases Antibodies  >12 publications with MAOA and Cardiovascular Diseases
 Parkinson Disease Antibodies  >11 publications with MAOA and Parkinson Disease
 Mental Retardation, X-Linked Antibodies  >11 publications with MAOA and Mental Retardation, X-Linked
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >211 publications with MAOA and Brain
 Nerve Antibodies  >50 publications with MAOA and Nerve
 Eye Antibodies  >18 publications with MAOA and Eye
 Lung Antibodies  >14 publications with MAOA and Lung
 Liver Antibodies  >11 publications with MAOA and Liver
 Prostate Antibodies  >10 publications with MAOA and Prostate
 Skin Antibodies  >10 publications with MAOA and Skin
 Muscle Antibodies  >9 publications with MAOA and Muscle
 Heart Antibodies  >8 publications with MAOA and Heart
 Ganglia Antibodies  >7 publications with MAOA and Ganglia
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