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anti-STK4 antibody :: Rabbit anti-Human, Mouse Mst1,2 phosphorylated Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS614580 anti-STK4 antibody
Unit / Price
0.1 mL  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mst1,2 phosphorylated (STK4), Polyclonal Antibody

 Also Known As   

Mst1,2 phosphorylated (Thr183,Thr180) (Mammalian Ste20-like Kinase)

 Product Synonym Names    Anti -Mst1,2 phosphorylated (Thr183,Thr180) (Mammalian Ste20-like Kinase)
 Product Gene Name   

anti-STK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (43595120..43708594). Location: 20q11.2-q13.2
 OMIM    604965
 3D Structure    ModBase 3D Structure for Q13043
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes endogenous levels of human Thr183 phosphorylated Mst1 and Thr180 phosphorylated Mst2 at 50kD. This antibody may crossreact with phosphorylated Mst3 and Mst4. Species Crossreactivity
 Purity/Purification    Affinity Purified
Protein A and peptide affinity chromatography
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol
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 Immunogen    Synthetic phospho-Thr183 peptide (KLH coupled) corresponding to residues surrounding threonine 183 of human Mst1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-STK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STK4 antibody

   Mammalian Ste20-like kinases, including Mst1-4, belong to the germinal center kinase (GCK) family. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast Ste20 kinase and other p21-activated kinases (1). The carboxy-terminal region of Mst1 and Mst2 contains a dimerization and an inhibitory domain, while the carboxy- terminal region of Mst3 and Mst4 are not well characterized (1-3). Dimerization and phosphorylation at the activation loop regulates translocation of Mst1 from the cytosol to the nucleus (3). Growing evidence indicates that Mst1, Mst2 and Mst3 are activated by apoptotic signals as well as other stress conditions (4-6). The full activation of Mst1 requires both phosphorylation and caspase-mediated cleavage (4). Sequence alignment of the activation loop of the GCK family indicates that Thr183 of Mst1 and Thr180 of Mst2 are the conserved residues and might be critical for the activity of the kinases. Activated Mst kinases may rely on p38 MAPK and JNK pathways to amplify apoptotic signals (5). Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognization site, inhibits caspase-mediated cleavage (4).
 Product Categories/Family for anti-STK4 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-STK4 antibody   

Western Blot (WB)

 Application Notes for anti-STK4 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for STK4. It may not necessarily be applicable to this product.
 NCBI GI #    1117791
 NCBI GeneID    6789
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 UniProt Primary Accession #    Q13043 [Other Products]
 UniProt Secondary Accession #    Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4; B2RCR8 [Other Products]
 UniProt Related Accession #    Q13043; Q15452; Q59FZ4; Q5H9T5; Q9BS84 [Other Products]
 Molecular Weight    55,630 Da [Similar Products]
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 NCBI Official Full Name    MST1
 NCBI Official Synonym Full Names    serine/threonine kinase 4
 NCBI Official Symbol    STK4 [Similar Products]
 NCBI Official Synonym Symbols   
KRS2; MST1; YSK3; DKFZp686A2068
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase 4; MST-1; OTTHUMP00000043418; OTTHUMP00000063226; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
 UniProt Protein Name    Serine/threonine-protein kinase 4
 UniProt Synonym Protein Names   
Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    STK4 [Similar Products]
 UniProt Synonym Gene Names    MST1 [Similar Products]
 UniProt Entry Name    STK4_HUMAN
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 NCBI Summary for STK4    The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq]
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 UniProt Comments for STK4    MST1: a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage.

Protein type: Protein kinase, STE; Kinase, protein; Autophagy; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 20q11.2-q13.2

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; identical protein binding; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: central nervous system development; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; patterning of blood vessels; keratinocyte differentiation; negative regulation of cell proliferation; peptidyl-serine phosphorylation; positive regulation of fat cell differentiation; neural tube formation

Disease: T-cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations
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 Research Articles on STK4    1. Phage microarrays containing colorectal cancer cDNA libraries were prepared to identify phage-expressed peptides recognized by tumor-specific autoantibodies from patient sera.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STK4 antibodyPathways associated with anti-STK4 antibody
 Reference Product  PubMed Publications
 RASSF1 antibody  >13 publications with STK4 and RASSF1
 CASP3 antibody  >11 publications with STK4 and CASP3
 SAV1 antibody  >7 publications with STK4 and SAV1
 RASSF5 antibody  >7 publications with STK4 and RASSF5
 LATS1 antibody  >7 publications with STK4 and LATS1
 MBP antibody  >4 publications with STK4 and MBP
 TP53 antibody  >1 publications with STK4 and TP53
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with anti-STK4 antibodyOrgans/Tissues associated with anti-STK4 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20 publications with STK4 and Neoplasms
 Carcinoma Antibodies  >7 publications with STK4 and Carcinoma
 Liver Neoplasms Antibodies  >4 publications with STK4 and Liver Neoplasms
 Colorectal Neoplasms Antibodies  >4 publications with STK4 and Colorectal Neoplasms
 Necrosis Antibodies  >3 publications with STK4 and Necrosis
 Liver Neoplasms, Experimental Antibodies  >3 publications with STK4 and Liver Neoplasms, Experimental
 Lung Diseases Antibodies  >2 publications with STK4 and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with STK4 and Lung Neoplasms
 Head and Neck Neoplasms Antibodies  >2 publications with STK4 and Head and Neck Neoplasms
 Colonic Neoplasms Antibodies  >2 publications with STK4 and Colonic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with STK4 and Blood
 Muscle Antibodies  >5 publications with STK4 and Muscle
 Lung Antibodies  >4 publications with STK4 and Lung
 Liver Antibodies  >4 publications with STK4 and Liver
 Prostate Antibodies  >3 publications with STK4 and Prostate
 Bone Antibodies  >3 publications with STK4 and Bone
 Kidney Antibodies  >2 publications with STK4 and Kidney
 Vascular Antibodies  >2 publications with STK4 and Vascular
 Thyroid Antibodies  >2 publications with STK4 and Thyroid
 Brain Antibodies  >2 publications with STK4 and Brain
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