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anti-MMRN1 antibody :: Rabbit anti-Human Multimerin 1 (MMRN1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2014921 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-MMRN1 antibody
Unit / Price
0.1 mg  /  $260 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Multimerin 1 (MMRN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Multimerin 1 (MMRN1)

 Product Gene Name   

anti-MMRN1 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Multimerin 1 (MMRN1) (MBS2006118)
FITC Conjugated Antibody: Multimerin 1 (MMRN1) (MBS2014921)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (90816003..90875780). Location: 4q22
 OMIM    601456
 3D Structure    ModBase 3D Structure for Q13201
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Label    FITC
 Traits    Liquid
 Immunogen    Recombinant MMRN1 (Ala807-Gly1053) expressed in E.coli.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-MMRN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MMRN1 antibody    FITC Antibody
 Applications Tested/Suitable for anti-MMRN1 antibody   

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-MMRN1 antibody    Western blotting: O.5-2ug/ml
Immunohistochemistry: 5-20ug/ml
Immunocytochemistry: 5-20ug/ml
Optimal working dilutions must be determined by end user.
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NCBI/Uniprot data below describe general gene information for MMRN1. It may not necessarily be applicable to this product.
 NCBI GI #    45269141
 NCBI GeneID    22915
 NCBI Accession #    NP_031377.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007351.2 [Other Products]
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 UniProt Primary Accession #    Q13201 [Other Products]
 UniProt Secondary Accession #    Q4W5L1; Q6P3T8; Q6ZUL9 [Other Products]
 UniProt Related Accession #    Q13201 [Other Products]
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 NCBI Official Full Name    multimerin-1
 NCBI Official Synonym Full Names    multimerin 1
 NCBI Official Symbol    MMRN1 [Similar Products]
 NCBI Official Synonym Symbols   
ECM; MMRN; GPIa*; EMILIN4
[Similar Products]
 NCBI Protein Information    multimerin-1; EMILIN-4; glycoprotein Ia*; endothelial cell multimerin; elastin microfibril interfacer 4; elastin microfibril interface located protein 4
 UniProt Protein Name    Multimerin-1
 UniProt Synonym Protein Names   
EMILIN-4; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; Endothelial cell multimerin
 Protein Family    Multimerin
 UniProt Gene Name    MMRN1 [Similar Products]
 UniProt Synonym Gene Names    ECM; EMILIN4; GPIA*; MMRN; Elastin microfibril interfacer 4; p-155; p155 [Similar Products]
 UniProt Entry Name    MMRN1_HUMAN
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 NCBI Summary for MMRN1    Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MMRN1    MMRN1: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: extracellular region

Biological Process: platelet activation; platelet degranulation; cell adhesion; blood coagulation
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 Research Articles on MMRN1    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MMRN1 antibodyDiseases associated with anti-MMRN1 antibody
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with MMRN1 and Mental Disorders
 Dementia Antibodies  >2 publications with MMRN1 and Dementia
 Adenocarcinoma Antibodies  >2 publications with MMRN1 and Adenocarcinoma
 Inflammation Antibodies  >2 publications with MMRN1 and Inflammation
 Ovarian Neoplasms Antibodies  >1 publications with MMRN1 and Ovarian Neoplasms
 Endometrial Neoplasms Antibodies  >1 publications with MMRN1 and Endometrial Neoplasms
 Atrophy Antibodies  >1 publications with MMRN1 and Atrophy
 Disease Models, Animal Antibodies  >1 publications with MMRN1 and Disease Models, Animal
 Genital Diseases, Female Antibodies  >1 publications with MMRN1 and Genital Diseases, Female
Organs/Tissues associated with anti-MMRN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with MMRN1 and Brain
 Vascular Antibodies  >2 publications with MMRN1 and Vascular
 Lung Antibodies  >1 publications with MMRN1 and Lung
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