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anti-UNC13D antibody :: Goat Munc13-4/UNC13D Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420652
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Munc13-4/UNC13D, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Munc13-4/UNC13D (C terminus) Antibody

 Product Synonym Names    Goat Anti-Munc13-4 / UNC13D (Internal) Antibody; UNC13D; Munc13-4; unc-13 homolog D (C. elegans); FHL3; HLH3; HPLH3; unc-13 homolog D; UNC13D antibody; Munc13-4 antibody; unc-13 homolog D (C. elegans) antibody; FHL3 antibody; HLH3 antibody; HPLH3 antibody; unc-13 homolog D antibody; Munc13-4; Munc13-4 / UNC13D (C terminus)
 Product Gene Name   

anti-UNC13D antibody

[Similar Products]
 Antibody/Peptide Pairs    Munc13-4 / UNC13D peptide (MBS428275) is used for blocking the activity of Munc13-4/UNC13D antibody (MBS420652)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KQASQHALRP AP
 OMIM    608897
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KQASQHALRPAP, from the C Terminus of the protein sequence according to NP_954712.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-UNC13D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UNC13D antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-UNC13D antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx.105kDa band observed in Human T-lymphocyte and HeLa lysates (calculated MW of 123kDa according to NP_954712.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-UNC13D antibody    (2ug/ml) staining of Human T-lymphocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Data provided by anonymous customer.
anti-UNC13D antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UNC13D. It may not necessarily be applicable to this product.
 NCBI GI #    46195765
 NCBI GeneID    201294
 NCBI Accession #    NP_954712.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199242.2 [Other Products]
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 UniProt Secondary Accession #    Q9H7K5; B4DWG9 [Other Products]
 UniProt Related Accession #    Q70J99 [Other Products]
 Molecular Weight    128,819 Da
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 NCBI Official Full Name    protein unc-13 homolog D
 NCBI Official Synonym Full Names    unc-13 homolog D
 NCBI Official Symbol    UNC13D [Similar Products]
 NCBI Official Synonym Symbols   
FHL3; HLH3; HPLH3; Munc13-4
[Similar Products]
 NCBI Protein Information    protein unc-13 homolog D
 UniProt Protein Name    Protein unc-13 homolog D
 UniProt Synonym Protein Names   
Munc13-4
 Protein Family    Protein
 UniProt Gene Name    UNC13D [Similar Products]
 UniProt Entry Name    UN13D_HUMAN
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 NCBI Summary for UNC13D    This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UNC13D    UNC13D: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Defects in UNC13D are the cause of familial hemophagocytic lymphohistiocytosis type 3 (FHL3); also known as HPLH3. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the unc-13 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: late endosome; lysosome; membrane; recycling endosome

Molecular Function: protein binding; Rab GTPase binding

Biological Process: defense response to virus; germinal center formation; granuloma formation; natural killer cell degranulation; phagocytosis; positive regulation of exocytosis; regulation of mast cell degranulation

Disease: Hemophagocytic Lymphohistiocytosis, Familial, 3
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 Research Articles on UNC13D    1. These studies highlight the need for RAB27A sequencing in patients with FHL with normal pigmentation and identify a critical binding site for Munc13-4 on Rab27a, revealing the molecular basis of this interaction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UNC13D antibodyPathways associated with anti-UNC13D antibody
 Reference Product  PubMed Publications
 STX11 antibody  >33 publications with UNC13D and STX11
 RAB27A antibody  >32 publications with UNC13D and RAB27A
 STXBP2 antibody  >28 publications with UNC13D and STXBP2
 FHL2 antibody  >16 publications with UNC13D and FHL2
 LYST antibody  >12 publications with UNC13D and LYST
 RAB27B antibody  >4 publications with UNC13D and RAB27B
 SYTL5 antibody  >1 publications with UNC13D and SYTL5
 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram
Diseases associated with anti-UNC13D antibodyOrgans/Tissues associated with anti-UNC13D antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >23 publications with UNC13D and Immune System Diseases
 Splenomegaly Antibodies  >10 publications with UNC13D and Splenomegaly
 Hemophagocytic lymphohistiocytosis, familial, 3 Antibodies  >8 publications with UNC13D and Hemophagocytic lymphohistiocytosis, familial, 3
 Inflammation Antibodies  >6 publications with UNC13D and Inflammation
 Vascular Diseases Antibodies  >4 publications with UNC13D and Vascular Diseases
 Necrosis Antibodies  >4 publications with UNC13D and Necrosis
 Disease Models, Animal Antibodies  >4 publications with UNC13D and Disease Models, Animal
 Fibrosis Antibodies  >3 publications with UNC13D and Fibrosis
 Hypertrophy Antibodies  >2 publications with UNC13D and Hypertrophy
 Liver Diseases Antibodies  >2 publications with UNC13D and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >71 publications with UNC13D and Blood
 Heart Antibodies  >7 publications with UNC13D and Heart
 Liver Antibodies  >5 publications with UNC13D and Liver
 Lung Antibodies  >4 publications with UNC13D and Lung
 Brain Antibodies  >3 publications with UNC13D and Brain
 Intestine Antibodies  >2 publications with UNC13D and Intestine
 Kidney Antibodies  >1 publications with UNC13D and Kidney
 Connective Tissue Antibodies  >1 publications with UNC13D and Connective Tissue
 Lymph Node Antibodies  >1 publications with UNC13D and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with UNC13D and Embryonic Tissue
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