AAC50618.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,446 Da
NCBI Official Full Name
mutY homolog
NCBI Official Synonym Full Names
mutY DNA glycosylase
NCBI Official Synonym Symbols
NCBI Protein Information
adenine DNA glycosylase
UniProt Protein Name
Adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Synonym Gene Names
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MUTYH
MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; EC 3.2.2.-; Hydrolase; Mitochondrial; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding
Biological Process: depurination; DNA repair; mismatch repair
Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma
Research Articles on MUTYH
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Products associated with anti-MUTYH antibody
Pathways associated with anti-MUTYH antibody
Diseases associated with anti-MUTYH antibody
Organs/Tissues associated with anti-MUTYH antibody
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