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anti-MYD88 antibody :: Rabbit MyD88 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128061
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MyD88, Polyclonal Antibody

★Popular Item★
 Also Known As   

MyD88 Polyclonal Antibody

 Product Gene Name   

anti-MYD88 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612260
 3D Structure    ModBase 3D Structure for Q99836
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Species    Human
 Immunogen    Recombinant Protein
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 Other Notes    Small volumes of anti-MYD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MYD88 antibody    Polyclonal
 Applications Tested/Suitable for anti-MYD88 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-MYD88 antibody    Western blot analysis of extracts of various cell lines, using MyD88 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-MYD88 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MYD88. It may not necessarily be applicable to this product.
 NCBI GI #    18202671
 NCBI GeneID    4615
 NCBI Accession #    Q99836.1 [Other Products]
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 UniProt Primary Accession #    Q99836 [Other Products]
 UniProt Secondary Accession #    P78397; Q53XS7; B4DKH8; B4DKU4; B4DQ60; B4DQ72; J3KPU4; J3KQ87; J3KQJ6 [Other Products]
 UniProt Related Accession #    Q99836 [Other Products]
 Molecular Weight    296
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 NCBI Official Full Name    Myeloid differentiation primary response protein MyD88
 NCBI Official Synonym Full Names    myeloid differentiation primary response 88
 NCBI Official Symbol    MYD88 [Similar Products]
 NCBI Official Synonym Symbols   
MYD88D
[Similar Products]
 NCBI Protein Information    myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88)
 UniProt Protein Name    Myeloid differentiation primary response protein MyD88
 Protein Family    Myeloid differentiation primary response protein
 UniProt Gene Name    MYD88 [Similar Products]
 UniProt Entry Name    MYD88_HUMAN
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 NCBI Summary for MYD88    This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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 UniProt Comments for MYD88    MYD88: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: plasma membrane; endosome membrane; cytosol

Molecular Function: identical protein binding; protein binding; death receptor binding

Biological Process: positive regulation of interleukin-17 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; signal transduction; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; cell surface receptor linked signal transduction; regulation of inflammatory response; positive regulation of interferon type I production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway; negative regulation of apoptosis

Disease: Macroglobulinemia, Waldenstrom, Susceptibility To, 1; Myd88 Deficiency
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 Research Articles on MYD88    1. MYD88 (L265P) mutation may have a role in progression of diffuse large B-cell lymphoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYD88 antibodyPathways associated with anti-MYD88 antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >1725 publications with MYD88 and TLR4
 TLR2 antibody  >1084 publications with MYD88 and TLR2
 TLR9 antibody  >462 publications with MYD88 and TLR9
 IRAK2 antibody  >271 publications with MYD88 and IRAK2
 TIRAP antibody  >220 publications with MYD88 and TIRAP
 IRAK1 antibody  >115 publications with MYD88 and IRAK1
 IRAK4 antibody  >112 publications with MYD88 and IRAK4
 IRF7 antibody  >80 publications with MYD88 and IRF7
 FADD antibody  >24 publications with MYD88 and FADD
 IL1R1 antibody  >10 publications with MYD88 and IL1R1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-MYD88 antibodyOrgans/Tissues associated with anti-MYD88 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1319 publications with MYD88 and Inflammation
 Necrosis Antibodies  >804 publications with MYD88 and Necrosis
 Disease Models, Animal Antibodies  >391 publications with MYD88 and Disease Models, Animal
 Lung Diseases Antibodies  >218 publications with MYD88 and Lung Diseases
 Cardiovascular Diseases Antibodies  >205 publications with MYD88 and Cardiovascular Diseases
 Liver Diseases Antibodies  >137 publications with MYD88 and Liver Diseases
 Pneumonia Antibodies  >111 publications with MYD88 and Pneumonia
 Brain Diseases Antibodies  >103 publications with MYD88 and Brain Diseases
 MYD88 Deficiency Antibodies  >88 publications with MYD88 and MYD88 Deficiency
 Fibrosis Antibodies  >85 publications with MYD88 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1413 publications with MYD88 and Blood
 Bone Antibodies  >517 publications with MYD88 and Bone
 Bone Marrow Antibodies  >480 publications with MYD88 and Bone Marrow
 Lung Antibodies  >350 publications with MYD88 and Lung
 Liver Antibodies  >275 publications with MYD88 and Liver
 Intestine Antibodies  >271 publications with MYD88 and Intestine
 Spleen Antibodies  >235 publications with MYD88 and Spleen
 Brain Antibodies  >187 publications with MYD88 and Brain
 Kidney Antibodies  >177 publications with MYD88 and Kidney
 Vascular Antibodies  >156 publications with MYD88 and Vascular
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