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anti-MYT1 antibody :: Rabbit anti-Human, Mouse Myelin Transcription Factor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2032431 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin Transcription Factor 1 (MYT1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Myelin Transcription Factor 1 (MYT1) Polyclonal Antibody

 Product Synonym Names    MTF1; MYTI; PLPB1; Proteolipid protein-binding protein
 Product Gene Name   

anti-MYT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8CFC2
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against MYT1. It has been selected for its ability to recognize MYT1 in immunohistochemical staining and western blotting.
 Purity/Purification    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Organism Species    Mouse
 Fragment    MYT1 (His905~Val1127)
 Quality Control    Content: The quality control contains recombinant MYT1 (His905~Val1127) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2067338
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4║C for frequent use.
Aliquot and store at -20║C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37░C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-MYT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYT1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, Immunopreciptation (IP)

 Application Notes for anti-MYT1 antibody    Western blotting: 0.5-5ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-MYT1 antibody    (Western Blot; Sample: Human A549 cell lysate; Primary Ab: 3ug/ml Rabbit Anti-Mouse MYT1 Antibody Second Ab: 0.2ug/mLáHRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
anti-MYT1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-MYT1 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-MYT1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MYT1 antibody    (Used in DAB staining on formalin fixed paraffin- embedded brain tissue)
anti-MYT1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MYT1. It may not necessarily be applicable to this product.
 NCBI GI #    284448128
 NCBI GeneID    17932
 NCBI Accession #    NP_001165086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171615.1 [Other Products]
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 UniProt Primary Accession #    Q8CFC2 [Other Products]
 UniProt Secondary Accession #    O08995; Q8CFH1; B0R0C3; B0R0C4 [Other Products]
 UniProt Related Accession #    Q8CFC2 [Other Products]
 Molecular Weight    119,547 Da
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 NCBI Official Full Name    myelin transcription factor 1 isoform 3
 NCBI Official Synonym Full Names    myelin transcription factor 1
 NCBI Official Symbol    Myt1 [Similar Products]
 NCBI Official Synonym Symbols   
Nzf2; Nzf2a; Nzf2b; Nztf2
[Similar Products]
 NCBI Protein Information    myelin transcription factor 1
 UniProt Protein Name    Myelin transcription factor 1
 UniProt Synonym Protein Names   
Neural zinc finger factor 2; NZF-2
 Protein Family    Myelin transcription factor
 UniProt Gene Name    Myt1 [Similar Products]
 UniProt Synonym Gene Names    Kiaa0835; Nzf2; MyT1; NZF-2 [Similar Products]
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 NCBI Summary for MYT1    This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
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 UniProt Comments for MYT1    PLPB1: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2 H4|2 103.77 cM

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: DNA binding; DNA binding transcription factor activity; metal ion binding; protein binding; zinc ion binding

Biological Process: cell differentiation; cell glucose homeostasis; endocrine pancreas development; multicellular organism development; nervous system development; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; regulation of hormone metabolic process; regulation of transcription, DNA-templated; transcription, DNA-dependent
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 Research Articles on MYT1    1. we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation...It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting the Notch1 receptor and many of its downstream targets
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MYT1 antibodyDiseases associated with anti-MYT1 antibody
 Products by Pathway  Pathway Diagram
 PI3K/Akt/mTOR Signaling Pathway antibodies  PI3K/Akt/mTOR Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with MYT1 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with MYT1 and Brain Diseases
 Neoplasms Antibodies  >11 publications with MYT1 and Neoplasms
 Nervous System Malformations Antibodies  >4 publications with MYT1 and Nervous System Malformations
 Peripheral Nervous System Diseases Antibodies  >4 publications with MYT1 and Peripheral Nervous System Diseases
 Drug Toxicity Antibodies  >3 publications with MYT1 and Drug Toxicity
 Disease Models, Animal Antibodies  >3 publications with MYT1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with MYT1 and Adenocarcinoma
 Skin Diseases Antibodies  >2 publications with MYT1 and Skin Diseases
 Liver Diseases Antibodies  >2 publications with MYT1 and Liver Diseases
Organs/Tissues associated with anti-MYT1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with MYT1 and Brain
 Embryonic Tissue Antibodies  >9 publications with MYT1 and Embryonic Tissue
 Pancreas Antibodies  >8 publications with MYT1 and Pancreas
 Spinal Cord Antibodies  >6 publications with MYT1 and Spinal Cord
 Fertilized Ovum Antibodies  >3 publications with MYT1 and Fertilized Ovum
 Eye Antibodies  >3 publications with MYT1 and Eye
 Skin Antibodies  >1 publications with MYT1 and Skin
 Stomach Antibodies  >1 publications with MYT1 and Stomach
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