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anti-MBP antibody :: Rabbit Myelin basic protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7601698 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.1 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin basic protein (MBP), Polyclonal Antibody

★Popular Item★
 Also Known As   

Myelin basic protein Rabbit Polyclonal

 Product Synonym Names    MBP, Myelin A1 protein, Myelin basic protein.
 Product Gene Name   

anti-MBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7601698 Technical Datasheet    Technical Datasheet PDF
 OMIM    159430
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat. Other species are not tested.
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 Specificity    Please decide specifity by homology.
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
PBS with 0.02% sodium azide and 50% glycerol pH 7.3
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 Immunogen    Myelin basic protein
 Calculated MW    34 kDa
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 Preparation and Storage    Store at -20C for 24 months. (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MBP antibody   

ELISA, WB, IHC, IF

 Application Notes for anti-MBP antibody    WB 1:500-1-2000
IHC 1:50-1:200
IF 1:50-1:200
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 Immunohistochemistry IHC of anti-MBP antibody    Immunohistochemistry of paraffin- embedded rat kidney tissue slide using MBS7601698( MBP Antibody) at dilution of 1:200
anti-MBP antibody Immunohistochemistry IHC (IHC) image
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 Testing Data TD of anti-MBP antibody    Mouse brain tissue were subjected to SDS PAGE followed by Western Blot with MBS7601698 (MBP Antibody) at dilution of 1:1000
anti-MBP antibody Testing Data TD image
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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    1162922
 NCBI GeneID    4155
 NCBI Accession #    AAC41944.1 [Other Products]
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 UniProt Secondary Accession #    Q15337; Q15338; Q15339; Q15340; A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4 [Other Products]
 UniProt Related Accession #    P02686 [Other Products]
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 NCBI Official Full Name    myelin basic protein
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    Golli-MBP; myelin basic protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
Myelin A1 protein; Myelin membrane encephalitogenic protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_HUMAN
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 NCBI Summary for MBP    The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP    The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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 Research Articles on MBP    1. IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MBP antibodyDiseases associated with anti-MBP antibody
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2800 publications with MBP and Nervous System Diseases
 Demyelinating Diseases Antibodies  >2019 publications with MBP and Demyelinating Diseases
 Brain Diseases Antibodies  >1786 publications with MBP and Brain Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1211 publications with MBP and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >736 publications with MBP and Cardiovascular Diseases
 Inflammation Antibodies  >526 publications with MBP and Inflammation
 Hypertension Antibodies  >428 publications with MBP and Hypertension
 Necrosis Antibodies  >275 publications with MBP and Necrosis
 Heart Diseases Antibodies  >206 publications with MBP and Heart Diseases
 Kidney Diseases Antibodies  >154 publications with MBP and Kidney Diseases
Organs/Tissues associated with anti-MBP antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3783 publications with MBP and Blood
 Brain Antibodies  >2035 publications with MBP and Brain
 Nerve Antibodies  >1496 publications with MBP and Nerve
 Heart Antibodies  >720 publications with MBP and Heart
 Spinal Cord Antibodies  >719 publications with MBP and Spinal Cord
 Kidney Antibodies  >271 publications with MBP and Kidney
 Muscle Antibodies  >260 publications with MBP and Muscle
 Spleen Antibodies  >252 publications with MBP and Spleen
 Lymph Node Antibodies  >244 publications with MBP and Lymph Node
 Lymph Antibodies  >243 publications with MBP and Lymph
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