Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MYH6 rightarrow Polyclonal MYH6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • NOS-II (Nos2) Antibody
 • Serum Albumin Antibody
 • Chaperonin 10 (CPN10) ELISA Kit
 • ADENOVIRUS HEXON Antibody
 • CD32 (Phospho-Tyr292) Antibody
 • Cathepsin A (CTSA) ELISA Kit
 • Mercaptopyruvate Sulfurtransferase (MPST) Recombinant Protein
 • Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QT... Recombinant Protein
 • Fibrillin 2 (FBN2) ELISA Kit
 • 5-hydroxytryptamine receptor 1A (Htr1a) Recombinant Protein
 • sushi domain containing 2 (SUSD2) ELISA Kit
 • Chymase 1, Mast Cell (CMA1) Antibody
 • VEGFR-1-Flt-1 (Peptide), soluble Antibody
 • Hepatocyte Nuclear Factor 1  Alpha (HNF1a) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MYH6 antibody :: anti-Rat Myosin Heavy Chain 6, Cardiac Muscle, Alpha (MYH6) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2008887 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-MYH6 antibody
Unit / Price
  DISCONTINUED
You will be redirected to our replacement product
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myosin Heavy Chain 6, Cardiac Muscle, Alpha (MYH6), Polyclonal Antibody

 Also Known As   

Biotin-Linked Antibody to Myosin Heavy Chain 6, Cardiac Muscle, Alpha (MYH6)

 Product Gene Name   

anti-MYH6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 14; NC_000014.8 (23849942..23878836, complement). Location: 14q12
 OMIM    160710
 3D Structure    ModBase 3D Structure for P13533
Section Bar
 Clonality    Polyclonal
 Species Reactivity    Rat
Section Bar
 Concentration    200ug/ml (lot specific)
Section Bar
Section Bar
 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-MYH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-MYH6 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-MYH6 antibody   

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MYH6. It may not necessarily be applicable to this product.
 NCBI GI #    156104908
 NCBI GeneID    4624
 NCBI Accession #    NP_002462.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002471.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P13533 [Other Products]
 UniProt Secondary Accession #    Q13943; Q14906; Q14907; A2RTX1; D9YZU2 [Other Products]
 UniProt Related Accession #    P13533 [Other Products]
 Molecular Weight    223,735 Da
Table BarTOPTable Bar
 NCBI Official Full Name    myosin-6
 NCBI Official Synonym Full Names    myosin, heavy chain 6, cardiac muscle, alpha
 NCBI Official Symbol    MYH6 [Similar Products]
 NCBI Official Synonym Symbols   
ASD3; MYHC; SSS3; CMH14; MYHCA; CMD1EE; alpha-MHC
[Similar Products]
 NCBI Protein Information    myosin-6; myHC-alpha; myosin heavy chain 6; myosin heavy chain, cardiac muscle alpha isoform; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
 UniProt Protein Name    Myosin-6
 UniProt Synonym Protein Names   
Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform
 Protein Family    Myosin
 UniProt Gene Name    MYH6 [Similar Products]
 UniProt Synonym Gene Names    MYHCA; MyHC-alpha [Similar Products]
 UniProt Entry Name    MYH6_HUMAN
Section Bar
 NCBI Summary for MYH6    Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Mar 2010]
Section Bar
 UniProt Comments for MYH6    MYH6: Muscle contraction. Defects in MYH6 are the cause of atrial septal defect type 3 (ASD3). ASD3 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Defects in MYH6 are the cause of familial hypertrophic cardiomyopathy type 14 (CMH14). It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations,and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH6 are the cause of cardiomyopathy dilated type 1EE (CMD1EE). It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH6 are the cause of susceptibility to sick sinus syndrome type 3 (SSS3). The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. MYH6 variations are associated with susceptibility to sick sinus syndrome (PubMed:21378987). The lifetime risk of being diagnosed with sick sinus syndrome is higher for carriers of variant p.Arg721Trp than for non-carriers (PubMed:21378987).

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: nucleoplasm; sarcomere; focal adhesion; myofibril; cytoplasm; stress fiber; muscle myosin complex; cytosol; myosin complex; Z disc

Molecular Function: calmodulin binding; microfilament motor activity; ATPase activity; actin-dependent ATPase activity; actin binding; protein kinase binding; ATP binding

Biological Process: adult heart development; striated muscle contraction; atrial cardiac muscle morphogenesis; regulation of heart rate; metabolic process; in utero embryonic development; Wnt receptor signaling pathway through beta-catenin; sarcomere organization; regulation of heart contraction; muscle filament sliding; visceral muscle development; BMP signaling pathway; regulation of ATPase activity; myofibril assembly; muscle contraction; cardiac muscle fiber development; regulation of blood pressure; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction

Disease: Cardiomyopathy, Familial Hypertrophic, 14; Sick Sinus Syndrome 3, Susceptibility To; Cardiomyopathy, Dilated, 1ee; Atrial Septal Defect 3; Cardiomyopathy, Familial Hypertrophic, 1
Table BarTOPTable Bar
 Research Articles on MYH6    1. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-MYH6 antibodyPathways associated with anti-MYH6 antibody
 Reference Product  PubMed Publications
 MYH7 antibody  >34 publications with MYH6 and MYH7
 TNNI3 antibody  >11 publications with MYH6 and TNNI3
 MYBPC3 antibody  >11 publications with MYH6 and MYBPC3
 MYL2 antibody  >8 publications with MYH6 and MYL2
 ACTC1 antibody  >4 publications with MYH6 and ACTC1
 MYL3 antibody  >3 publications with MYH6 and MYL3
 MYH2 antibody  >2 publications with MYH6 and MYH2
 MYH13 antibody  >1 publications with MYH6 and MYH13
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
Diseases associated with anti-MYH6 antibodyOrgans/Tissues associated with anti-MYH6 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >41 publications with MYH6 and Cardiovascular Diseases
 Heart Diseases Antibodies  >40 publications with MYH6 and Heart Diseases
 Cardiomegaly Antibodies  >16 publications with MYH6 and Cardiomegaly
 Hypertrophy Antibodies  >14 publications with MYH6 and Hypertrophy
 Cardiomyopathies Antibodies  >13 publications with MYH6 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >12 publications with MYH6 and Cardiomyopathy, Hypertrophic
 Heart Failure Antibodies  >11 publications with MYH6 and Heart Failure
 Cardiomyopathy, Dilated Antibodies  >11 publications with MYH6 and Cardiomyopathy, Dilated
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >5 publications with MYH6 and Cardiomyopathy, Hypertrophic, Familial
 Heart Septal Defects, Atrial Antibodies  >5 publications with MYH6 and Heart Septal Defects, Atrial
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >70 publications with MYH6 and Heart
 Muscle Antibodies  >61 publications with MYH6 and Muscle
 Embryonic Tissue Antibodies  >12 publications with MYH6 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions