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anti-MYO9B antibody :: Goat Myosin IXB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420830
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myosin IXB (MYO9B), Polyclonal Antibody

 Also Known As   

Goat anti-Myosin IXB Antibody

 Product Synonym Names    MYO9B; myosin IXB; CELIAC4; MYR5; myosin; celiac disease 4; MYO9B antibody; myosin IXB antibody; CELIAC4 antibody; MYR5 antibody; myosin antibody; celiac disease 4 antibody; Myosin IXB; Myosin IXB
 Product Gene Name   

anti-MYO9B antibody

[Similar Products]
 Antibody/Peptide Pairs    Myosin IXB peptide (MBS425056) is used for blocking the activity of Myosin IXB antibody (MBS420830)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KNDFEPVKQS KAQ
 OMIM    602129
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KNDFEPVKQSKAQ, from the internal region of the protein sequence according to NP_004136.2; NP_001123537.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_004136.2; NP_001123537.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-MYO9B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYO9B antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MYO9B antibody    Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Approx 200kDa band observed in Human Liver lysates (calculated MW of 243kDa according to NP_004136.2). Recommended concentration: 2-6ug/ml.
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 Western Blot (WB) of anti-MYO9B antibody    (2ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-MYO9B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MYO9B. It may not necessarily be applicable to this product.
 NCBI GI #    33356170
 NCBI GeneID    4650
 NCBI Accession #    NP_004136.2 [Other Products]
 NCBI Related Accession #    NP_001123537.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004145.3 [Other Products]
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 UniProt Secondary Accession #    O75314; Q9NUJ2; Q9UHN0 [Other Products]
 UniProt Related Accession #    Q13459 [Other Products]
 Molecular Weight    229,143 Da
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 NCBI Official Full Name    unconventional myosin-IXb isoform 1
 NCBI Official Synonym Full Names    myosin IXB
 NCBI Official Symbol    MYO9B [Similar Products]
 NCBI Official Synonym Symbols   
MYR5; CELIAC4
[Similar Products]
 NCBI Protein Information    unconventional myosin-IXb
 UniProt Protein Name    Unconventional myosin-IXb
 UniProt Synonym Protein Names   
Unconventional myosin-9b
 Protein Family    Unconventional myosin
 UniProt Gene Name    MYO9B [Similar Products]
 UniProt Synonym Gene Names    MYR5 [Similar Products]
 UniProt Entry Name    MYO9B_HUMAN
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 NCBI Summary for MYO9B    This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for MYO9B    MYO9B: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; Actin-binding; Motility/polarity/chemotaxis; Motor; GAPs

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: actin cytoskeleton; actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; myosin complex; perinuclear region of cytoplasm; ruffle

Molecular Function: actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATP-dependent protein binding; ATPase activity; calmodulin binding; GTPase activator activity; microfilament motor activity; protein binding; protein homodimerization activity; Rho GTPase binding; Roundabout binding; zinc ion binding

Biological Process: actin filament-based movement; ARF protein signal transduction; metabolic process; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction

Disease: Celiac Disease, Susceptibility To, 4
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 Research Articles on MYO9B    1. newly defined SLIT/ROBO/Myo9b/RhoA signaling pathway that restricts lung cancer progression and metastasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYO9B antibodyPathways associated with anti-MYO9B antibody
 Reference Product  PubMed Publications
 RHOA antibody  >8 publications with MYO9B and RHOA
 RHOB antibody  >1 publications with MYO9B and RHOB
 RHOC antibody  >1 publications with MYO9B and RHOC
 CDC42 antibody  >1 publications with MYO9B and CDC42
 Products by Pathway  Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
Diseases associated with anti-MYO9B antibodyOrgans/Tissues associated with anti-MYO9B antibody
 Disease Name  Pubmed Publications
 Celiac Disease Antibodies  >23 publications with MYO9B and Celiac Disease
 Immune System Diseases Antibodies  >6 publications with MYO9B and Immune System Diseases
 Disease Models, Animal Antibodies  >2 publications with MYO9B and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >1 publications with MYO9B and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >1 publications with MYO9B and Congenital Abnormalities
 Carcinoma Antibodies  >1 publications with MYO9B and Carcinoma
 Weight Loss Antibodies  >1 publications with MYO9B and Weight Loss
 Precancerous Conditions Antibodies  >1 publications with MYO9B and Precancerous Conditions
 Neurobehavioral Manifestations Antibodies  >1 publications with MYO9B and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >8 publications with MYO9B and Intestine
 Blood Antibodies  >7 publications with MYO9B and Blood
 Muscle Antibodies  >3 publications with MYO9B and Muscle
 Bone Antibodies  >3 publications with MYO9B and Bone
 Brain Antibodies  >3 publications with MYO9B and Brain
 Spleen Antibodies  >2 publications with MYO9B and Spleen
 Bone Marrow Antibodies  >2 publications with MYO9B and Bone Marrow
 Nerve Antibodies  >1 publications with MYO9B and Nerve
 Thymus Antibodies  >1 publications with MYO9B and Thymus
 Prostate Antibodies  >1 publications with MYO9B and Prostate
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