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anti-NAGase antibody :: Rabbit anti-Rat N-Acetyl Beta-D-Glucosaminidase (NAGase) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2001439 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N-Acetyl Beta-D-Glucosaminidase (NAGase), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to N-Acetyl Beta-D-Glucosaminidase (NAGase)

 Product Gene Name   

anti-NAGase antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S- AL EERESERNAN PASVSGASLE PSAAPAPGED NPSGAGAAAG TGAAGGARRF LCGVVEGFYG RPWVMEQRKE LFRRLQKWEL NTYLYAPKDD YKHRMFWREM YSVEEAEQLM TLISAAREYE IEFIYAISPG LDITFSNPKE VSTLKRKLDQ VSQFGCRSFA LLFDDIDHNM CAADKEVFSS FAHAQVSITN EIYQYLGEPE TFLFCPTEYC GT
 3D Structure    ModBase 3D Structure for Q8VIJ5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    The antibody is a rabbit polyclonal antibody raised against NAGase. It has been selected for its ability to recognize NAGase in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant NAGase (Ala19~Thr222) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2036715
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-NAGase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NAGase antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-NAGase antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-NAGase antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-NAGase antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NAGase antibody    (Figure.DAB staining on IHC-P. Samples: Rat Tissue)
anti-NAGase antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NAGase. It may not necessarily be applicable to this product.
 NCBI GI #    18777747
 NCBI GeneID    154968
 NCBI Accession #    NP_571979.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_131904.1 [Other Products]
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 UniProt Primary Accession #    Q8VIJ5 [Other Products]
 UniProt Related Accession #    Q8VIJ5 [Other Products]
 Molecular Weight    91,993 Da
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 NCBI Official Full Name    protein O-GlcNAcase
 NCBI Official Synonym Full Names    meningioma expressed antigen 5 (hyaluronidase)
 NCBI Official Symbol    Mgea5 [Similar Products]
 NCBI Official Synonym Symbols   
OGA; Ncoat; O-GLCNACASE
[Similar Products]
 NCBI Protein Information    protein O-GlcNAcase
 UniProt Protein Name    Protein O-GlcNAcase
 UniProt Synonym Protein Names   
Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Bifunctional protein NCOAT
 UniProt Gene Name    Mgea5 [Similar Products]
 UniProt Synonym Gene Names    Hexc; Mea5; OGA [Similar Products]
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 NCBI Summary for NAGase    plays a role in insulin secretion; may be involved in secretion of other glucose regulated hormones [RGD, Feb 2006]
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 UniProt Comments for NAGase    OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; EC 3.2.1.169; EC 3.2.1.52; Hydrolase

Chromosomal Location of Human Ortholog: 1q54

Cellular Component: cytosol; membrane; mitochondrion; nucleus

Molecular Function: beta-N-acetylglucosaminidase activity; histone acetyltransferase activity

Biological Process: aging; dATP metabolic process; histone acetylation; N-acetylglucosamine metabolic process; negative regulation of protein glycosylation; positive regulation of calcium ion transport; positive regulation of cell killing; positive regulation of DNA metabolic process; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein deglycosylation; protein targeting to membrane; response to steroid hormone
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 Research Articles on NAGase    1. This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NAGase antibodyPathways associated with anti-NAGase antibody
 Reference Product  PubMed Publications
 Ogt antibody  >11 publications with NAGase and Ogt
 Products by Pathway  Pathway Diagram
 Insulin Resistance Pathway antibodies  Insulin Resistance Pathway Diagram
Diseases associated with anti-NAGase antibodyOrgans/Tissues associated with anti-NAGase antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with NAGase and Nervous System Diseases
 Inflammation Antibodies  >4 publications with NAGase and Inflammation
 Kidney Diseases Antibodies  >3 publications with NAGase and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with NAGase and Neoplasms, Experimental
 Pain Antibodies  >1 publications with NAGase and Pain
 Renal Insufficiency Antibodies  >1 publications with NAGase and Renal Insufficiency
 Heart Diseases Antibodies  >1 publications with NAGase and Heart Diseases
 Hemorrhage Antibodies  >1 publications with NAGase and Hemorrhage
 Neoplasm Invasiveness Antibodies  >1 publications with NAGase and Neoplasm Invasiveness
 Disease Models, Animal Antibodies  >1 publications with NAGase and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with NAGase and Kidney
 Embryonic Tissue Antibodies  >2 publications with NAGase and Embryonic Tissue
 Prostate Antibodies  >2 publications with NAGase and Prostate
 Connective Tissue Antibodies  >2 publications with NAGase and Connective Tissue
 Brain Antibodies  >2 publications with NAGase and Brain
 Testis Antibodies  >1 publications with NAGase and Testis
 Lung Antibodies  >1 publications with NAGase and Lung
 Liver Antibodies  >1 publications with NAGase and Liver
 Artery Antibodies  >1 publications with NAGase and Artery
 Adipose Tissue Antibodies  >1 publications with NAGase and Adipose Tissue
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