NP_076288.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,395 Da
NCBI Official Full Name
protein O-GlcNAcase
NCBI Official Synonym Full Names
meningioma expressed antigen 5 (hyaluronidase)
NCBI Protein Information
protein O-GlcNAcase
UniProt Protein Name
Protein O-GlcNAcase
UniProt Synonym Protein Names
Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Bifunctional protein NCOAT
UniProt Synonym Gene Names
UniProt Comments for NAGase
OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Acetyltransferase; EC 3.2.1.169; EC 3.2.1.52; Hydrolase
Chromosomal Location of Human Ortholog: 19 C3|19 38.75 cM
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleus
Molecular Function: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity; beta-N-acetylglucosaminidase activity; beta-N-acetylhexosaminidase activity; histone acetyltransferase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; protein binding
Biological Process: dATP metabolic process; glycoprotein metabolic process; metabolic process; N-acetylglucosamine metabolic process; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; positive regulation of calcium ion transport; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of DNA metabolic process; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein deglycosylation; protein targeting to membrane
Research Articles on NAGase
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Products associated with anti-NAGase antibody
Pathways associated with anti-NAGase antibody
Diseases associated with anti-NAGase antibody
Organs/Tissues associated with anti-NAGase antibody
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