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anti-CDH2 antibody :: Rabbit N-Cadherin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS472035
Testing Data
Unit / Price
0.1 mL  /  $280 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N-Cadherin (CDH2), Polyclonal Antibody

 Also Known As   

N-Cadherin (a.a. 853-864) [Conserved Site: E-Cadherin (a.a. 828-839)]

 Product Synonym Names    Cadherin-2; Neural-Cadherin; CD325 antigen
 Product Gene Name   

anti-CDH2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (25530930..25757445, complement). Location: 18q11.2
 OMIM    114020
 3D Structure    ModBase 3D Structure for P19022
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody was affinity purified using N-cadherin (a.a. 853-864) peptide. In western blots, the antibody detects a 130 kDa* band corresponding to N-cadherin in human endothelial cells and detects a 120 kDa band corresponding to E-cadherin in human A431 cells.
 Purity/Purification    Affinity Purified
 Form/Format    Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    N-Cadherin synthetic peptide (coupled to carrier protein) corresponding to amino acids 853 to 864 in human N-cadherin. This sequence is conserved in rat and mouse N-cadherin, as well as in E-, P-, and Rcadherin from human, rat, and mouse.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-CDH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDH2 antibody

   Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. This region induces clustering and also binds to the protein p120 catenin. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton. Many cadherins are regulated by phosphorylation, including N-cadherin and E-cadherin. N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886. Phosphorylation of Tyr-860 can disrupt cadherin binding to beta-catenin. Since many of these tyrosine sites are conserved in the cadherin family, phosphorylation of these sites may be critical for cadherin function.
 Applications Tested/Suitable for anti-CDH2 antibody   

ELISA, Western Blot

 Application Notes for anti-CDH2 antibody    ELISA: 1:2000
Western Blot: 1:1000
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 Testing Data of anti-CDH2 antibody    anti-CDH2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CDH2. It may not necessarily be applicable to this product.
 NCBI GI #    253483
 NCBI GeneID    1000
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 UniProt Primary Accession #    P19022 [Other Products]
 UniProt Secondary Accession #    Q14923; Q8N173; B0YIY6 [Other Products]
 UniProt Related Accession #    P19022 [Other Products]
 Molecular Weight    99,809 Da [Similar Products]
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 NCBI Official Full Name    N-cadherin
 NCBI Official Synonym Full Names    cadherin 2, type 1, N-cadherin (neuronal)
 NCBI Official Symbol    CDH2 [Similar Products]
 NCBI Official Synonym Symbols   
CDHN; NCAD; CD325; CDw325
[Similar Products]
 NCBI Protein Information    cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; OTTHUMP00000066304; OTTHUMP00000067378; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal
 UniProt Protein Name    Cadherin-2
 UniProt Synonym Protein Names   
CDw325; Neural cadherin
 Protein Family    Cadherin
 UniProt Gene Name    CDH2 [Similar Products]
 UniProt Synonym Gene Names    CDHN; NCAD [Similar Products]
 UniProt Entry Name    CADH2_HUMAN
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 NCBI Summary for CDH2    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq]
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 UniProt Comments for CDH2    Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density

Subunit structure: Interacts with CDCP1. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway

By similarity. Ref.10

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Sequence similarities: Contains 5 cadherin domains.
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Product References and Citations for anti-CDH2 antibody

   • Xu, Y. et al. (1997) J. Biol. Chem. 272(21):13463
• Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264
• Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261
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 Research Articles on CDH2    1. The positive expression rate of N-cadherin is decreased in osteosarcoma, and is is closely correlated with metastasis and prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH2 antibodyPathways associated with anti-CDH2 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >44 publications with CDH2 and CTNNB1
 CDH4 antibody  >3 publications with CDH2 and CDH4
 JUP antibody  >2 publications with CDH2 and JUP
 CDH11 antibody  >2 publications with CDH2 and CDH11
 CTNNA1 antibody  >1 publications with CDH2 and CTNNA1
 ARVCF antibody  >1 publications with CDH2 and ARVCF
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
Diseases associated with anti-CDH2 antibodyOrgans/Tissues associated with anti-CDH2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >63 publications with CDH2 and Neoplasms
 Carcinoma Antibodies  >25 publications with CDH2 and Carcinoma
 Adenocarcinoma Antibodies  >18 publications with CDH2 and Adenocarcinoma
 Female Urogenital Diseases Antibodies  >11 publications with CDH2 and Female Urogenital Diseases
 Neuroectodermal Tumors Antibodies  >11 publications with CDH2 and Neuroectodermal Tumors
 Cardiovascular Diseases Antibodies  >11 publications with CDH2 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >11 publications with CDH2 and Neoplasm Metastasis
 Skin Diseases Antibodies  >9 publications with CDH2 and Skin Diseases
 Endocrine Gland Neoplasms Antibodies  >9 publications with CDH2 and Endocrine Gland Neoplasms
 Lung Neoplasms Antibodies  >9 publications with CDH2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with CDH2 and Brain
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